ArticleBMJ open2024
Grading carcinoembryonic antigen levels can enhance the effectiveness of prognostic stratification in patients with colorectal cancer: a single-centre retrospective study.
Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Kinase-based molecular subtyping and a prognostic risk model in colorectal cancer with functional validation of PLK4.Translational cancer research · 2026Article
- Survival prediction in stage II/III rectal cancer: Role of immune-inflammatory biomarkers post neoadjuvant chemoradiotherapy.Oncology letters · 2026Article
- Investigation of a methylated BCAT1 and IKZF1 circulating tumour DNA blood test for monitoring treatment response in patients with colorectal cancer.Journal of cancer research and clinical oncology · 2026Article
- T4bN0 colon cancer shows worse survival than T1-2N1 disease: a multicenter real-world study in China.Translational cancer research · 2026Article
- CT-Based Radiomic Signatures Associated with Serum CEA Status in Colon Cancer.Diagnostics (Basel, Switzerland) · 2026Article
- Survival impact of radiotherapy for patients with de novo metastatic rectal cancer.Annals of coloproctology · 2026Article
- Comprehensive Landscape of Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer: From Genomics to Multi-Omics Integration in Precision Medicine.Journal of personalized medicine · 2026Review
- Letter to the editor.Clinical oral investigations · 2026Article
- A clinical-molecular nomogram for predicting early recurrence following resection of initially unresectable colorectal liver metastases.Therapeutic advances in medical oncology · 2026Article
- Clinical characteristics and risk factors in patients with colon cancer liver metastases.Frontiers in oncology · 2026Article
- Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Early-Onset Colorectal Cancer.Journal of gastrointestinal cancer · 2025Article
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5 authors.
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Abstract
objectivesThis study developed a refined carcinoembryonic antigen (CEA) grading system using CEA cut-off points of 5, 20 and 50 ng/mL and to explore the prognostic value of CEA grading in predicting the progression-free survival (PFS) and overall survival (OS) of colorectal cancer (CRC) patients.
designA retrospective cohort study.
settingFirst Affiliated Hospital of Guangxi Medical University.
participants1107 CRC patients who received surgical treatment. MATERIALS AND
methodsSurvival analysis was conducted using the Kaplan-Meier method and compared using the log-rank test. A Cox regression model with a 95% CI was used to evaluate the independent prognostic risk factors for CRC. Prognostic nomograms were constructed to predict the 1-5-year PFS/OS.
resultsElevated serum CEA levels are often indicative of recurrence and death in CRC patients. Higher CEA levels were significantly associated with more aggressive tumour phenotypes. The CEA grading system was an independent predictor of prognosis in CRC patients and effectively stratified PFS (62.0% vs 51.2% vs 33.7% vs 20.2%, p<0.001) and OS (64.7% vs 54.4% vs 36.6% vs 22.5%, p<0.001) in CRC patients. As the CEA grade increased, the risk of poor prognosis gradually increased in a gradient manner, with an approximately 10% difference in risk grade between each CEA grade. The internal validation cohort further confirmed that CEA grade remains an effective prognostic factor for the survival of CRC patients. Prognostic nomograms, which integrate individual characteristics, tumour features and CEA grading, provide a more comprehensive prognostic evaluation for CRC patients.
conclusionsThe CEA grading system is an independent predictor of prognosis for CRC patients and can effectively stratify PFS and OS.
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