Evidence map›Paper›PMID 39476959›Full record

ArticleThe Journal of biological chemistry2024

Transcriptomic and metabolic signatures of neural cells cultured under a physiologic-like environment.

Emilio Fernandez, Moussa Warde, Israel Manjarres-Raza, Veronica Bobo-Jimenez, Maria Martinez-Luna, Carlos Vicente-Gutierrez, Dario Garcia-Rodriguez, Daniel Jimenez-Blasco, Angeles Almeida, Juan P Bolaños

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emilio FernandezInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Moussa WardeInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Israel Manjarres-RazaInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Veronica Bobo-JimenezInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Maria Martinez-LunaInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.
Carlos Vicente-GutierrezInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.
Dario Garcia-RodriguezInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Daniel Jimenez-BlascoInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Angeles AlmeidaInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Juan P BolañosInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jbolanos@usal.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cultured brain cells are used conventionally to investigate fundamental neurobiology and identify therapeutic targets against neural diseases. However, standard culture conditions do not simulate the natural cell microenvironment, thus hampering in vivo translational insight. Major weaknesses include atmospheric (21%) O

Indexed as

AstrocytesNeuronsTranscriptomeAnimalsCells, CulturedCoculture TechniquesGlycolysisMiceMitochondriaOxygenOxygenastrocyteenergy metabolismglycolysishypoxianeurontranscriptomics

Identifiers

PMID39476959
PMCPMC11742299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.