Evidence map›Paper›PMID 39476938›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2025

Volume calibration with cardiac MRI versus hypertonic saline for right ventricular pressure-volume loops with exercise: Impact on ventricular function and ventricular-vascular coupling.

Farhan Raza, Chris G Lechuga, Oliver Wieben, Naomi C Chesler

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Farhan RazaDepartment of Medicine-Cardiovascular Division, University of Wisconsin Hospital, Madison, Wisconsin. Electronic address: fraza@medicine.wisc.edu.
Chris G LechugaEdwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), Department of Biomedical Engineering, University of California, Irvine, California.
Oliver WiebenDepartment of Radiology, University of Wisconsin Hospital, Madison, Wisconsin.
Naomi C CheslerEdwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), Department of Biomedical Engineering, University of California, Irvine, California.

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7M
Multiscale Mechanobiology of Right Ventricular FailureR01HL154624 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Anthony J. BAKER, DANIEL A BEARD · 2020 to 2026
$4.9M
Mechanobiological mechanisms of pulmonary hypertension secondary to left heart failureR01HL147590 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CHESLER, NAOMI C · 2020 to 2023
$2.7M
Training Program in Cardiovascular Applied Research and EntrepreneurshipT32HL116270 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUGHES, CHRISTOPHER C. W. · 2013 to 2022
$1.6M
NCATS NIH HHS KL2 TR002374NCATS NIH HHS UL1 TR002373NHLBI NIH HHS R01 HL147590NHLBI NIH HHS R01 HL154624NHLBI NIH HHS T32 HL116270
6 · The paper itself

Abstract

backgroundRight ventricular (RV) pressure-volume (PV) loops require postacquisition volume calibration by cardiac MRI (CMR) or hypertonic saline (HS). We defined the impact of these 2 volume calibration methods on rest-to-exercise ventricular contractility (end-systolic elastance: Ees), arterial afterload (Ea), and coupling (Ees/Ea).

methodsIn a prospective study, 82 RV PV-loop datapoints (rest, exercise stages every 25 W, and recovery) and CMR were acquired in 19 participants.

resultsIn comparison to CMR, HS-based calibration overestimated RV end-systolic volume at rest, mean (SD) by +38 ml (48) and end-diastolic volume by +46 ml (68), resulting in underestimated right ventricular ejection fraction (RVEF) by -8%. However, Ees and Ea were similar at rest (r

conclusionsIn comparison to CMR (gold-standard), HS-based calibration underestimates RVEF at rest; however, it is a robust approach for measuring coupling and RV reserve.

Indexed as

ExerciseHeart VentriclesMagnetic Resonance ImagingMagnetic Resonance Imaging, CineStroke VolumeVentricular Function, RightVentricular PressureAdultCalibrationExercise TestFemaleHumansMaleMiddle AgedProspective StudiesSaline Solution, HypertonicSaline Solution, Hypertoniccardiac MRIhypertonic salinepressure-volume loopsventricular-vascular couplingvolume calibration

Identifiers

PMID39476938
PMCPMC11850197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.