ArticleCell2024
An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania.
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In one paragraph
Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Advances in natural killer cell immunotherapy for hematologic malignancies.Cancer biology & therapy · 2026Review
- Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles.American journal of human genetics · 2026Article
- Protein language models accurately predict polymorphic peptide-modulated NK cell receptor-HLA class I interaction strengths.Science advances · 2026Article
- Equity, ethics and the promise of partnership in genomic medicine.Nature genetics · 2025Article
- Post-translational modification of NK cell receptors offers clues to antigenic specificity riddle.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Liyen LohDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Philippa M SaundersDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Camilla FaoroInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Neus Font-PorteriasDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Neda Nemat-GorganiDepartment of Structural Biology and Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Genelle F HarrisonDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Suraju SadeeqDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Luca HensenDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Shu Cheng WongDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Jacqueline WidjajaDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
E Bridie ClemensDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Shiying ZhuInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Katherine M KichulaDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Sudan TaoDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.
Faming ZhuBlood Center of Zhejiang Province, Hangzhou, Zhejiang, China.
Gonzalo Montero-MartinStanford Blood Centre, Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Marcelo Fernandez-VinaStanford Blood Centre, Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Lisbeth A GuethleinDepartment of Structural Biology and Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Julian P VivianInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Jane DaviesMenzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia; Department of Infectious Diseases, Royal Darwin Hospital, Casuarina, NT 0810, Australia.
Alexander J MentzerWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK.
Stephen J OppenheimerInstitute of Social and Cultural Anthropology, School of Anthropology and Museum Ethnography, University of Oxford, Oxford OX3 7LF, UK.
William PomatPapua New Guinea Institute of Medical Research, Post Office Box 60, Goroka, Papua New Guinea.
Alexander G IoannidisDepartment of Biomolecular Engineering, UC Santa Cruz, Santa Cruz, CA 95064, USA.
Carmina Barberena-JonasAdvanced Genomics Unit, Center for Research and Advanced Studies (CINVESTAV), Irapuato 36821, Mexico.
Oceanian Genome Variation Project Consortium
Andrés Moreno-EstradaAdvanced Genomics Unit, Center for Research and Advanced Studies (CINVESTAV), Irapuato 36821, Mexico.
Adrian MillerJawun Research Centre, Central Queensland University, Cairns, QLD 4870, Australia.
Peter ParhamDepartment of Structural Biology and Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Jamie RossjohnInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK. Electronic address: jamie.rossjohn@monash.edu.
Steven Y C TongVictorian Infectious Diseases Service, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3000, Australia; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3000, Australia. Electronic address: steven.tong@unimelb.edu.au.
Katherine KedzierskaDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Electronic address: kkedz@unimelb.edu.au.
Andrew G BrooksDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Electronic address: agbrooks@unimelb.edu.au.
Paul J NormanDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA; Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Department of Structural Biology and Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address: paul.norman@cuanschutz.edu.
Funding
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8MSTRUCTURAL BIOLOGY OF HLA-A,B ANTIGENSR01AI017892 · NIAID · STANFORD UNIVERSITY · PI PARHAM, PETER R · 1985 to 2019
$6.1MEvolution and Function of Immunogenetic Diversity across the Eastern HemisphereR01AI151549 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2022 to 2026
$3.9MNIAID NIH HHS R01 AI017892NIAID NIH HHS R01 AI151549NIDDK NIH HHS P30 DK116073
Abstract
Genetic variation in host immunity impacts the disproportionate burden of infectious diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptors (KIRs) are key regulators of natural killer (NK) cells, which mediate early infection control. How this variation impacts their responses across populations is unclear. We show that HLA-A
Indexed as
AllelesKiller Cells, NaturalAustraliaGenetic VariationHistocompatibility Antigens Class IHLA-A24 AntigenHumansIndigenous PeoplesOceaniaReceptors, KIR3DL1Selection, GeneticHistocompatibility Antigens Class IHLA-A24 AntigenKIR3DL1 protein, humanReceptors, KIR3DL1First Nations AustraliansHLAimmunogenetic diversityinfluenza virusintrogressionKIRNK cellsOceania
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.