Evidence map›Paper›PMID 39476703›Full record

ArticleEpilepsy & behavior : E&B2024

Perceptions of reproductive risk among women with epilepsy of childbearing age.

Chloé E Hill, Chun Chieh Lin, Shriya Suresh, Stephanie Shatzman, Nishad Shaheid, Sung Hyun Seo, Linda M Selwa, Temenuzhka Mihaylova

Abstract read
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In one paragraph

Article in Epilepsy & behavior : E&B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chloé E HillDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA. Electronic address: chloehi@med.umich.edu.
Chun Chieh LinDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA; Department of Neurology, The Ohio State University, Columbus, OH, USA.
Shriya SureshDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Stephanie ShatzmanDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Nishad ShaheidDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA; OhioHealth Physician Group, Mansfield, OH, USA.
Sung Hyun SeoDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Linda M SelwaDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Temenuzhka MihaylovaDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.

Funding

Optimizing Care for Patients with Drug-Resistant EpilepsyK23NS126495 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Chloe E Hill · 2023 to 2026
$881k
NINDS NIH HHS K23 NS126495
6 · The paper itself

Abstract

backgroundHaving children or planning to have children may raise many questions for women with epilepsy. Seizures and antiseizure medications (ASMs) impact contraception, fetal/early childhood development, and maternal health. Little is known regarding patients' perspectives about reproductive risk and how those perspectives influence reproductive decision-making.

methodsAs a quality improvement initiative, we distributed an electronic survey within our health system to women ages 21-45 with a primary diagnosis of epilepsy/seizures. We then performed an exploratory research study to investigate perceptions of risk of epilepsy and ASMs on reproductive health and decision making. Additionally, we looked at clinical characteristics as possible predictors of fear impacting reproductive decisions.

resultsThere were 267 responses (32% responder rate); after exclusion criteria, 233 respondents were included in the study. There were mixed responses about how fear of ASM teratogenicity impacted decisions about having children (33% very much, 34% a little, 33% not at all). While 45% responded that fear of having a child with epilepsy/seizures did not at all affect decisions about having children, for 24% this very much affected their decision. In total 42% of respondents reported they had had children. When we evaluated the impact of certain clinical characteristics, we found ASM number and valproic acid use impacted reproductive decision making, while other expected characteristics (e.g., drug-refractoriness and convulsive seizures) did not. DISCUSSION: We found variation in perceptions of risk. Overall, our data support the very personalized nature of preferences and the need for individualized counseling when guiding patients in reproductive decision making.

Indexed as

AnticonvulsantsEpilepsyAdultDecision MakingFemaleHealth Knowledge, Attitudes, PracticeHumansMiddle AgedPerceptionPregnancySurveys and QuestionnairesYoung AdultAnticonvulsantsAntiseizure medicationReproductive riskTeratogenicityWomen with epilepsy

Identifiers

PMID39476703
PMCPMC12594484

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.