Evidence map›Paper›PMID 39476536›Full record

ArticleEBioMedicine2024

Association between prenatal maternal sleep quality, neonatal uncinate fasciculus white matter, and infant negative emotionality.

Melissa Nevarez-Brewster, Catherine H Demers, LillyBelle K Deer, Özlü Aran, Robert J Gallop, Mercedes Hoeflich Haase, Khalid Al-Ali, Maria M Bagonis, John H Gilmore, M Camille Hoffman and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Social Determinants of Health and Early Brain Development.Pediatric clinics of North America · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Melissa Nevarez-BrewsterDepartment of Psychology, University of Denver, USA. Electronic address: melissa.nevarezbrewster@du.edu.
Catherine H DemersDepartment of Psychology, University of Denver, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, USA. Electronic address: catherine.demers@cuanschutz.edu.
LillyBelle K DeerDepartment of Psychology, University of Denver, USA.
Özlü AranDepartment of Psychology, University of Denver, USA.
Robert J GallopDepartment of Mathematics, West Chester University, West Chester, PA, USA.
Mercedes Hoeflich HaaseDepartment of Psychiatry, University of North Carolina, Chapel Hill, USA.
Khalid Al-AliDepartment of Psychiatry, School of Medicine, Indiana University, USA.
Maria M BagonisDepartment of Psychiatry, University of North Carolina, Chapel Hill, USA.
John H GilmoreDepartment of Psychiatry, University of North Carolina, Chapel Hill, USA.
M Camille HoffmanDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, USA; Division of Maternal and Foetal Medicine, Department of Obstetrics and Gynaecology, University of Colorado Denver School of Medicine, USA.
Martin A StynerDepartment of Psychiatry, University of North Carolina, Chapel Hill, USA; Department of Computer Science, University of North Carolina, Chapel Hill, USA.
Benjamin L HankinDepartment of Psychology, University of Illinois at Urbana, Champaign, USA.
Elysia Poggi DavisDepartment of Psychology, University of Denver, USA; Department of Paediatrics, University of California, Irvine, USA.

Funding

Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk MechanismsR01MH109662 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, HANKIN, BENJAMIN L · 2017 to 2021
$4.0M
Reducing maternal prenatal depression to improve child cardiovascular healthR01HL155744 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, DOOM, JENALEE RAE · 2021 to 2025
$3.6M
The Colorado Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084226 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI JUDITH G. REGENSTEINER, Nanette F. Santoro · 2023 to 2026
$2.5M
Biostatistics and Mental Health Neuroimaging and Genomics Training GrantT32MH106440 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE, KOSOROK, MICHAEL R · 2015 to 2019
$970k
Placental CRH and child cardiovascular disease risk and obesogenic eating behaviorsF32HL165844 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DEER, LILLYBELLE KUULEI · 2022 to 2024
$165k
Prenatal maternal depression exposure and infant neurocircuitry developmentF32MH125572 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DEMERS, CATHERINE · 2021 to 2021
$66k
NHLBI NIH HHS F32 HL165844NHLBI NIH HHS R01 HL155744NIAMS NIH HHS K12 AR084226NICHD NIH HHS P50 HD103573NIMH NIH HHS F32 MH125572NIMH NIH HHS R01 MH109662NIMH NIH HHS T32 MH106440
6 · The paper itself

Abstract

backgroundPoor prenatal maternal sleep is a pervasive, yet modifiable, health concern affecting maternal and foetal wellbeing. Experimental rodent studies demonstrate that prenatal maternal sleep deprivation affects offspring brain development and leads to adverse outcomes, including increased anxiety-like behaviour. We examined the relation between prenatal maternal sleep quality and neonatal white matter development and subsequent infant negative emotionality.

methodsParticipants included 116 mother-infant (53% female) dyads. Prenatal sleep quality was prospectively assessed three times during gestation (16, 29, and 35 gestational weeks) using the Pittsburgh Sleep Quality Index. Neonatal white matter, as indexed by fractional anisotropy (FA), was assessed via diffusion weighted magnetic resonance imaging. Negative emotionality was measured via behavioural observation and maternal report when the infant was 6-months of age.

findingsMore prenatal sleep problems across pregnancy were associated with higher neonatal FA in the uncinate fasciculus (left: b = 0.20, p = .004; right: b = 0.15, p = .027). Higher neonatal uncinate FA was linked to infant negative emotionality, and uncinate FA partially mediated the association between prenatal maternal sleep and behavioural observation of infant negative emotionality.

interpretationFindings highlight prenatal sleep as an environmental signal that affects the developing neonatal brain and later infant negative emotionality.

fundingNational Institutes of Health (R01MH109662, R01HL155744, P50HD103573, K12AR084226, F32 Training fellowships MH125572, HL165844, MH106440, and diversity supplement R01HL155744-01S1).

Indexed as

EmotionsSleepWhite MatterAdultFemaleHumansInfantInfant, NewbornMaleMothersPregnancyPrenatal Exposure Delayed EffectsDiffusion imagingIntergenerational transmissionNegative emotionalityNeonatal magnetic resonance imagingPrenatal sleepUncinate fasciculus

Identifiers

PMID39476536
PMCPMC11564983

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.