Evidence map›Paper›PMID 39476460›Full record

ArticlePatient education and counseling2025

Developing a supportive virtual human to deliver clinical trial education for older women and other populations historically excluded from research.

Emma G Bryan, Huan Chen, Melissa Vilaro, Haoran Chu, Gabriella Grillo, Palani Te, Miriam Buhr, Stephen Anton, Janice L Krieger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Patient education and counseling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Digital Tools and Strategies for Engaging Patients in Cancer Clinical Trials.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emma G BryanDepartment of Advertising, University of Florida, Gainesville, USA. Electronic address: emma.bryan@ufl.edu.
Huan ChenDepartment of Public Relations, University of Florida, USA. Electronic address: huanchen@jou.ufl.edu.
Melissa VilaroDepartment of Family, Youth and Community Sciences, University of Florida, USA. Electronic address: mgraveley@ufl.edu.
Haoran ChuDepartment of Public Relations, University of Florida, USA. Electronic address: chu.h@ufl.edu.
Gabriella GrilloDepartment of Health Services Research, Management and Policy, University of Florida, USA. Electronic address: gabriellagrillo0@gmail.com.
Palani TeDepartment of Advertising, University of Florida, Gainesville, USA. Electronic address: palani0814@ufl.edu.
Miriam BuhrUniversity of Florida Health Cancer Center, University of Florida, USA.
Stephen AntonDepartment of Physiology and Aging, University of Florida, USA. Electronic address: santon@ufl.edu.
Janice L KriegerDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, USA. Electronic address: krieger.janice@mayo.edu.

Funding

Tailoring Recruitment Communication using Virtual Human Technology to Increase Participation of Older Minority Adults in Clinical TrialsR24AG074867 · NIA · UNIVERSITY OF FLORIDA · PI ANTON, STEPHEN D, RAUP-KRIEGER, JANICE LEE · 2021 to 2023
$2.0M
NIA NIH HHS R24 AG074867
6 · The paper itself

Abstract

objectiveThis study aimed to identify communication strategies that virtual humans (VHs) discussing clinical trials can use to foster positive relationships with older women to better deliver research education.

methodsA template thematic analysis and matrix analysis of 10 interviews and 3 focus groups with 37 older women identifying as White non-Hispanic, Black, or Hispanic/Latinx were conducted.

resultsVHs can foster positive relationships with older women during clinical trial education by communicating social support. At the same time, VHs should convey credibility. Factors shaping experiences of the VHs' support and credibility include race and ethnicity, comfort with research and technology, and current health status.

conclusionDeploying communication strategies that foster positive relationships between VHs and older women are crucial for optimizing the use of VHs during clinical trial education for populations historically excluded from research. PRACTICE IMPLICATIONS: This study provides a cohesive framework guiding the development of VH clinical trial educators for older women to meet their communication needs. The framework may extend to other populations historically excluded from research and real human clinical trial educators.

fundingThis work was supported by the National Institute on Aging National Institutes of Health, Award R24AG074867 (PIs: Krieger and Anton).

Indexed as

Clinical Trials as TopicCommunicationFocus GroupsPatient Education as TopicSocial SupportAgedAged, 80 and overBlack or African AmericanFemaleHispanic or LatinoHumansInterviews as TopicMiddle AgedQualitative ResearchUser-Computer InterfaceVirtual RealityClinical trial educationClinical trial recruitmentOlder adultsRelationship-building communicationSocial support communicationVirtual humans

Identifiers

PMID39476460
PMCPMC12989962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.