Evidence map›Paper›PMID 39476334›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Evaluation of Anti-Alzheimer's Potential of Azo-Stilbene-Thioflavin-T derived Multifunctional Molecules: Synthesis, Metal and Aβ Species Binding and Cholinesterase Activity.

Monika Rana, Karna Terpstra, Citlali Gutierrez, Kerui Xu, Hemant Arya, Tarun K Bhatt, Liviu M Mirica, Anuj K Sharma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Monika RanaDepartment of Chemistry, Central University of Rajasthan, Bandarsindri, Ajmer, 305817, India.ORCID https://orcid.org/0000-0002-2777-663X
Karna TerpstraDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois, 61801, USA.
Citlali GutierrezDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois, 61801, USA.
Kerui XuDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois, 61801, USA.
Hemant AryaDepartment of Biotechnology, Central University of Rajasthan, Bandarsindri, Ajmer, 305817, India.
Tarun K BhattDepartment of Biotechnology, Central University of Rajasthan, Bandarsindri, Ajmer, 305817, India.
Liviu M MiricaDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois, 61801, USA.
Anuj K SharmaDepartment of Chemistry, Central University of Rajasthan, Bandarsindri, Ajmer, 305817, India.ORCID https://orcid.org/0000-0002-5090-3713

Funding

Blood-Brain Barrier Permeable Multimodal Imaging Agents for Neurodegenerative DiseasesRF1AG083937 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MIRICA, LIVIU M. · 2023 to 2023
$1.8M
NOVEL BIFUNCTIONAL CHEMICAL AGENTS AS THERANOSTIC TOOLS FOR AMYLOID DISEASESR01GM114588 · NIGMS · WASHINGTON UNIVERSITY · PI MIRICA, LIVIU M. · 2015 to 2019
$1.4M
Council of Scientific and Industrial Research, India 09/1131(0030)-19-EMR-IIndian Council of Medical Research EM/Dev/IG/18/1623/2023National Institute of Health R01GM114588 and RF1AG083937NIA NIH HHS RF1 AG083937NIGMS NIH HHS R01 GM114588SERB India EMR/2016/001452; CRG/2022/004355
6 · The paper itself

Abstract

Inhibition of amyloid β (Aβ) aggregation and cholinesterase activity are two major therapeutic targets for Alzheimer's disease (AD). Multifunctional Molecules (MFMs) specifically designed to address other contributing factors, such as metal ion induced abnormalities, oxidative stress, toxic Aβ aggregates etc. are very much required. Several multifunctional molecules have been developed using different molecular scaffolds. Reported herein is a new series of four MFMs based on ThT, Azo-stilbene and metal ion chelating pockets. The synthesis, characterization, and metal chelation ability for [Cu

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAzo CompoundsCholinesterase InhibitorsStilbenesAcetylcholinesteraseAnimalsBenzothiazolesChelating AgentsCopperHumansMiceMolecular Docking SimulationZincAcetylcholinesteraseAmyloid beta-PeptidesAzo CompoundsBenzothiazolesChelating AgentsCholinesterase InhibitorsCopperStilbenesthioflavin TZincAcetylcholinesterase InhibitorsAlzheimer's diseaseAmyloid-β aggregationMetal ChelatorsMultifunctional Molecules (MFMs)

Identifiers

PMID39476334
PMCPMC12435589

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.