Evidence map›Paper›PMID 39476297›Full record

ArticleCell biology and toxicology2024

NPR1 promotes cisplatin resistance by inhibiting PARL-mediated mitophagy-dependent ferroptosis in gastric cancer.

Chengwei Wu, Song Wang, Tao Huang, Xinran Xi, Lishuai Xu, Jiawei Wang, Yinfen Hou, Yabin Xia, Li Xu, Luman Wang and 1 more

Abstract read
In one paragraph

Article in Cell biology and toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Review
  5. Review
  6. Article
  7. Article
  8. Targeting ferroptosis inInternational journal of oncology · 2026
    Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chengwei Wu *Department of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, No.2, Zheshan West Road, Wuhu, 241001, Anhui, China.
Song Wang *Department of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, No.2, Zheshan West Road, Wuhu, 241001, Anhui, China.
Tao Huang *Anhui Province Key Laboratory of Non-Coding RNA Basic and Clinical Transformation, Wuhu, Anhui, China.
Xinran Xi *Anhui Province Key Laboratory of Non-Coding RNA Basic and Clinical Transformation, Wuhu, Anhui, China.
Lishuai XuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, No.2, Zheshan West Road, Wuhu, 241001, Anhui, China.
Jiawei WangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, No.2, Zheshan West Road, Wuhu, 241001, Anhui, China.
Yinfen HouDepartment of Medical Examination Center, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
Yabin XiaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, No.2, Zheshan West Road, Wuhu, 241001, Anhui, China.
Li XuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, No.2, Zheshan West Road, Wuhu, 241001, Anhui, China.
Luman WangDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xiaoxu HuangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, No.2, Zheshan West Road, Wuhu, 241001, Anhui, China. xiaoxuhuang1984@163.com.

Funding

Anhui Provincial Health Commission Provincial Financial Key Projects AHWJ2023A10126Natural Science Foundation of China 82372707Natural Science Research Project of Higher Education in Anhui Province 2023AH051771Natural Science Research Project of Higher Education in Anhui Province KJ2021A0857
6 · The paper itself

Abstract

Cisplatin-based chemotherapy serves as the standard of care for individuals with advanced stages of gastric cancer. Nevertheless, the emergence of chemoresistance in GC has detrimental impacts on prognosis, yet the underlying mechanisms governing this phenomenon remain elusive. Level of mitophagy and ferroptosis of GC cells were detected by fluorescence, flow cytometry, GSH, MDA, Fe

Indexed as

CisplatinDrug Resistance, NeoplasmFerroptosisMitophagyStomach NeoplasmsAnimalsAntineoplastic AgentsCell Line, TumorHumansReceptors, Atrial Natriuretic FactorUbiquitinationAntineoplastic AgentsCisplatinReceptors, Atrial Natriuretic FactorChemoresistanceFerroptosisGastric CancerMitophagyNPR1PARLUbiquitination

Identifiers

PMID39476297
PMCPMC11525271

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.