ReviewReviews in endocrine & metabolic disorders2024
Prolactin: structure, receptors, and functions.
Review in Reviews in endocrine & metabolic disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Positive emotion interventions as a non-pharmacological approach to boost colostrum secretion: a randomized controlled trial.Scientific reports · 2026Trial
- Prolactin levels and female sexual distress: associations with sexual knowledge and behaviors.Sexual medicine · 2026Article
- Zika Virus Inoculation During Pregnancy Impaired Maternal Care and Altered Prolactin and Corticosterone Levels in Rats.Developmental neurobiology · 2026Article
- CREBZF/c-Jun modulates ApoE-mediated cholesterol transport to influence female steroid hormone synthesis.Zoological research · 2026Article
- The therapeutic pipeline in migraine: What does the future hold?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Increase in serum prolactin levels as a potential biomarker in Crohn's disease: a prospective cohort study.Frontiers in medicine · 2026Article
- The Metabolic-Immune Axis: Amino Acids and Immune Cell Dynamics in Mammary Gland Development and Remodeling.International journal of biological sciences · 2026Review
- Prolactin-induced platelet activation and endothelial dysfunction in coronary artery disease: insights into PKC and TXA2 pathways.American journal of translational research · 2026Article
- From the perspective of prolactin: a view on obesity.Frontiers in endocrinology · 2026Review
- Correlation between serum prolactin and the systemic immune-inflammation index in diabetic kidney disease: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Reproductive dysfunction in hemodialysis: endocrine mechanisms, clinical features, and therapeutic approaches.Renal failure · 2025Review
- Hyperprolactinemia and Brain Health: Exploring the Gut-Brain Axis and Therapeutic Strategies.Molecular neurobiology · 2025Review
- Baseline testosterone levels as a predictor of hypogonadism resolution in male patients with isolated hyperprolactinemia.Pituitary · 2025Article
- DietaryVeterinary sciences · 2025Article
- Exercise ameliorates hepatic lipid accumulation via upregulating serum PRL and activating hepatic PRLR-mediated JAK2/STAT5 signaling pathway in NAFLD mice.Frontiers in pharmacology · 2025Article
- Prolactin drives cortical neuron maturation and dendritic development during murine embryonic stem cell differentiation.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also by other peripheral tissues. PRL binds directly to a unique transmembrane receptor (PRLR), and the JAK2/signal transducer and activator of transcription 5 (Stat5) pathway is considered the major downstream pathway for PRLR signaling. To a lesser extent, PRL may be cleaved into the shorter 16-kDa PRL, also called vasoinhibin, whose signaling is not fully known. According to rodent models of PRL signaling inactivation and the identification of human genetic alterations in PRL signaling, a growing number of biological processes are partly mediated by PRL or its downstream effectors. In this review, we focused on PRL structure and signaling and its canonical function in reproduction. In addition to regulating reproductive functions, PRL also plays a role in behavior, notably in initiating nurturing and maternal behavior. We also included recent insights into PRL function in several fields, including migraines, metabolic homeostasis, inflammatory and autoimmune disease, and cancer. Despite the complexity of understanding the many functions of PRL, new research in this field offers interesting perspectives on physiological and pathophysiological processes.
Indexed as
Identifiers
39476210What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.