Evidence map›Paper›PMID 39476150›Full record

ArticleMemorias do Instituto Oswaldo Cruz2024

First comparative genomics analysis of Corynebacterium auriscanis.

Ana Lua de Oliveira Vinhal, Max Roberto Batista de Araújo, Evandro Bento Rodrigues, Diogo Luiz de Carvalho Castro, Carine Rodrigues Pereira, Dircéia Aparecida Costa Custódio, Elaine Maria Seles Dorneles, Flávia Figueira Aburjaile, Bertram Brenig, Vasco Azevedo and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ana Lua de Oliveira VinhalUniversidade Federal de Minas Gerais, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brasil.
Max Roberto Batista de AraújoUniversidade Federal de Minas Gerais, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brasil.
Evandro Bento RodriguesUniversidade Federal de Minas Gerais, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brasil.
Diogo Luiz de Carvalho CastroUniversidade Federal de Minas Gerais, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brasil.
Carine Rodrigues PereiraUniversidade Federal de Lavras, Faculdade de Zootecnia e Medicina Veterinária, Departamento de Medicina Veterinária, Lavras, MG, Brasil.
Dircéia Aparecida Costa CustódioUniversidade Federal de Lavras, Faculdade de Zootecnia e Medicina Veterinária, Departamento de Medicina Veterinária, Lavras, MG, Brasil.
Elaine Maria Seles DornelesUniversidade Federal de Lavras, Faculdade de Zootecnia e Medicina Veterinária, Departamento de Medicina Veterinária, Lavras, MG, Brasil.
Flávia Figueira AburjaileUniversidade Federal de Minas Gerais, Escola de Veterinária, Belo Horizonte, MG, Brasil.
Bertram BrenigUniversity of Göttingen, Institute of Veterinary Medicine, Göttingen, Germany.
Vasco AzevedoUniversidade Federal de Minas Gerais, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brasil.
Marcus Vinicius Canário VianaUniversidade Federal de Minas Gerais, Departamento de Genética, Ecologia e Evolução, Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0002-7017-6437

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCorynebacterium auriscanis is a bacterial species frequently isolated from dogs with external otitis or dermatitis and a zoonotic pathogen transmitted by dog bite. It is considered an opportunistic pathogen, but its pathogenicity mechanisms are poorly studied. Comparative genomics can identify virulence and niche factors that could contribute to understanding its lifestyle.

objectivesThe objectives of this project was to compare genomes of C. auriscanis to identify genes related to its virulence and lifestyle.

methodsThe genome of strain 32 was sequenced using Illumina HiSeq 2500 (Illumina, CA, USA) and assembled using Unicycler. The two other non-redundant genomes from the same species available in GenBank were included in the analysis. All genomes were annotated and checked for taxonomy, assembly quality, mobile elements, CRISPR-Cas systems, and virulence and antimicrobial resistance genes. The virulence genes in the three genomes were compared to the ones from other pathogens commonly isolated with C. auriscanis.

findingsThe species has 42 virulence factors that can be classified as niche factors, due to the absence of true virulence factors found in primary pathogens. The gene rbpA could confer basal levels of resistance to rifampin. MAIN

conclusionsThe absence of true virulence factors in the three genomes suggests C. auriscanis has an opportunistic pathogen lifestyle.

Indexed as

CorynebacteriumGenome, BacterialGenomicsVirulence FactorsAnimalsCorynebacterium InfectionsDogsVirulenceVirulence Factors

Identifiers

PMID39476150
PMCPMC11508509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.