ArticleBrazilian dental journal2024
The Use of Mesenchymal Stromal/Stem Cells (MSC) for Periodontal and Peri-implant Regeneration: Scoping Review.
Article in Brazilian dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Biomaterials for Guided Tissue Regeneration and Guided Bone Regeneration: A Review.Dentistry journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The necessity for regenerating peri-implant and periodontal tissues is increasingly apparent. Periodontal diseases can result in a significant loss of clinical attachment level, and tissue regeneration stands as the ultimate goal of periodontal therapy. With the rise of osseointegration, the prosthetic rehabilitation of missing teeth using dental implants has surged, leading to a frequent need for alveolar bone regeneration around implants. This review assessed studies reporting various sources of mesenchymal stromal/stem cells (MSC) and their potential in regenerating periodontal and peri-implant bone tissue. A search was conducted across seven databases spanning the past decade. Three authors independently screened all identified titles and abstracts for eligibility, generating tables to summarize included studies in animals and humans separately. A total of 55 articles were chosen for final evaluation, showcasing five origins of MSC used in humans and animals for regenerating periodontal tissues and peri-implant bone, using different types of scaffolds. Overall, research from the past decades supports the effectiveness of MSC in promoting periodontal and peri-implant regeneration. However, the impact of MSC on regenerative therapies in humans is still in its initial stages. Future research should optimize MSC application protocols by combining techniques, such as the use of nanomedicine and 3D printing for tissue engineering. Clinical studies should also understand the long-term effects and compare MSC therapies with current treatment modalities. By addressing these areas, the scientific community can ensure that MSC therapies are both safe and effective, ultimately enhancing therapeutic strategies and treatment outcomes in Periodontology and Implantology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.