Evidence map›Paper›PMID 39476094›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Management of severe traumatic brain injury in pediatric patients: an evidence-based approach.

Ana Paula de Carvalho Panzeri Carlotti, Vivian Henriques do Amaral, Ana Paula de Carvalho Canela Balzi, Cintia Johnston, Fabiane Allioti Regalio, Maíra Freire Cardoso, Juliana Ferreira Ferranti, Patrícia Zamberlan, Alfredo Elias Gilio, Luiz Marcelo Sá Malbouisson and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ana Paula de Carvalho Panzeri CarlottiDivision of Critical Care Medicine, Department of Pediatrics, Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, Avenida dos Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil. apcarlotti@fmrp.usp.br.ORCID http://orcid.org/0000-0003-2760-8801
Vivian Henriques do AmaralSurgical Pediatric Intensive Care Unit, Division of Anesthesiology, Instituto Central of Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Ana Paula de Carvalho Canela BalziSurgical Pediatric Intensive Care Unit, Division of Anesthesiology, Instituto Central of Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Cintia JohnstonPediatric Critical Care Unit, Department of Pediatrics, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Fabiane Allioti RegalioSurgical Pediatric Intensive Care Unit, Division of Anesthesiology, Instituto Central of Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Maíra Freire CardosoSurgical Pediatric Intensive Care Unit, Division of Anesthesiology, Instituto Central of Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Juliana Ferreira FerrantiPediatric Critical Care Unit, Department of Pediatrics, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Patrícia ZamberlanPediatric Critical Care Unit, Department of Pediatrics, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Alfredo Elias GilioDepartment of Pediatrics, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Luiz Marcelo Sá MalbouissonSurgical Pediatric Intensive Care Unit, Division of Anesthesiology, Instituto Central of Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Artur Figueiredo DelgadoPediatric Critical Care Unit, Department of Pediatrics, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Werther Brunow de CarvalhoPediatric Critical Care Unit, Department of Pediatrics, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Brazilian Pediatric Intensive Care Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraumatic brain injury (TBI) is a major cause of death and disability worldwide. The decision-making process in the management of severe TBI must be based on the best available evidence to minimize the occurrence of secondary brain injuries. However, healthcare approaches to managing TBI patients exhibit considerable variation.

methodsOver an 18-month period, a multidisciplinary panel consisting of medical doctors, physiotherapists, nutritional therapists, and nurses performed a comprehensive review on various subtopics concerning TBI. The panel identified primary questions to be addressed using the Population, Intervention, Control, and Outcome (PICO) format and applied the Evidence to Decision (EtD) framework criteria for evaluating interventions. Subsequently, the panel formulated recommendations for the management of severe TBI in children.

resultsFourteen evidence-based recommendations have been devised for the management of severe TBI in children, covering nine topics, including imaging studies, neuromonitoring, prophylactic anticonvulsant use, hyperosmolar therapy, sedation and analgesia, mechanical ventilation strategies, nutritional therapy, blood transfusion, and decompressive craniectomy. For each topic, the panel provided clinical recommendations and identified research priorities.

conclusionsThis review offers evidence-based strategies aimed to guide practitioners in the care of children who suffer from severe TBI.

Indexed as

Brain Injuries, TraumaticEvidence-Based Emergency MedicinePatient Care ManagementPediatric Emergency MedicineHumansInterdisciplinary CommunicationEvidence-basedManagementMonitoringTraumatic brain injury

Identifiers

PMID39476094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.