ReviewEnvironmental science & technology2024
The Global Threat from the Irreversible Accumulation of Trifluoroacetic Acid (TFA).
Review in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed.
- Radical chemistry in atmospheric ice analogs forms persistent trifluoroacetic acid.Chemical science · 2026Article
- Implementation of a mixed-mode liquid chromatography-based analysis to assess fluorinated inorganic anions and (ultra)-short chain PFAS contamination in surface waters.Analytical and bioanalytical chemistry · 2026Article
- Unique fluoroalkyl substituents: is there life after CFChemical science · 2026Review
- Reply to Li et al.: Fluorinated liquid crystal monomers highlight a need for more data on emerging PFAS.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Environmental burden of the neuro-conda trial.Critical care (London, England) · 2026Article
- Trifluoroacetate mediated reduction of atherosclerosis in mice.Nature communications · 2026Article
- A Programmable Luminescent Sensing Platform via Site-Selective Modular Installation in Metal-Organic Frameworks.Angewandte Chemie (International ed. in English) · 2026Article
- Per- and Polyfluoroalkyl Substances (PFAS) Exposure Profiles and Their Predictors in a Study of US Volunteer Firefighters.American journal of industrial medicine · 2026Article
- Determination of Fluorinated Pesticide Residues and Their Selected Transformation Products in High-Water-Content Foods Using Complementary LC-MS/MS and GC-MS/MS Methods.Foods (Basel, Switzerland) · 2026Article
- Persistent and Mobile Organic Contaminants: Quantification and Nontarget Analysis in Greater Boston Drinking and Surface Water.ACS environmental Au · 2026Article
- TFA Generation and Deposition over Europe May Currently See a Greater Influence from HFO-1234yf than HFC-134a.Environmental science & technology letters · 2026Article
- Trifluoroacetic Acid (TFA) Exceeds All Other Extractable Organofluorine in Drinking Water from Eastern Massachusetts, United States.Environmental science & technology letters · 2026Article
- The Versatile Structural World of Methanedi- and Trisulfonic Acid and Their Salts.ChemistryOpen · 2026Article
- Weather-Specific Individual Exposure to Organic Contaminants in Fine Particulate Matter by Nontarget Screening and Risk Prioritization.Environment & health (Washington, D.C.) · 2026Article
- A Liquid-Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water.Analytical chemistry · 2026Article
- Toward Rational Design of PFAS-Extracting Deep Eutectic Solvents: Bifunctional Architectures, Leaching Constraints, and Scalability Targets.Molecules (Basel, Switzerland) · 2026Article
- Photocatalytic Vanadium-Mediated Amination of Benzene With Hydroxylamine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Bidirectional skeletal remodelling of SFChemical science · 2026Article
- PFAS Toxicity: What's True, What's Not, and What Really Matters.Environmental science & technology · 2026Review
- Ion chromatography high-resolution mass spectrometry-quality assurance by co-injection of internal standards.Analytical and bioanalytical chemistry · 2026Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trifluoroacetic acid (TFA) is a persistent and mobile substance that has been increasing in concentration within diverse environmental media, including rain, soils, human serum, plants, plant-based foods, and drinking water. Currently, TFA concentrations are orders of magnitude higher than those of other per- and polyfluoroalkyl substances (PFAS). This accumulation is due to many PFAS having TFA as a transformation product, including several fluorinated gases (F-gases), pesticides, pharmaceuticals, and industrial chemicals, in addition to direct release of industrially produced TFA. Due to TFA's extreme persistence and ongoing emissions, concentrations are increasing irreversibly. What remains less clear are the thresholds where irreversible effects on local or global scales occur. There are indications from mammalian toxicity studies that TFA is toxic to reproduction and that it exhibits liver toxicity. Ecotoxicity data are scarce, with most data being for aquatic systems; fewer data are available for terrestrial plants, where TFA bioaccumulates most readily. Collectively, these trends imply that TFA meets the criteria of a planetary boundary threat for novel entities because of increasing planetary-scale exposure, where potential irreversible disruptive impacts on vital earth system processes could occur. The rational response to this is to instigate binding actions to reduce the emissions of TFA and its many precursors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.