ArticleCell reports2024
Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia.
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34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Revisiting insulin resistance in human cancer cachexia - a systematic review and meta-analysis.Acta oncologica (Stockholm, Sweden) · 2025Pooled it
- Fibro-Adipogenic Progenitor Ablation Triggers Muscle Atrophy Through Cell Death-Induced Inflammation.Journal of cachexia, sarcopenia and muscle · 2026Article
- Understanding cachexia and muscle dysfunction in the context of metastatic breast cancer.Cancer metastasis reviews · 2026Review
- Mechanisms of Impaired Skeletal Muscle Regeneration and Therapeutic Approaches in Aging and Chronic Disease.Pharmaceuticals (Basel, Switzerland) · 2026Review
- C26 and CT26 colorectal cancer models exhibit divergent cachexia phenotypes, intramuscular inflammation, and protein turnover signaling.bioRxiv : the preprint server for biology · 2026Article
- Single-Cell RNA-Sequencing Reveals Cachectic Satellite Cell Population in Muscle of Male Mice With Cancer Cachexia.Journal of cachexia, sarcopenia and muscle · 2026Article
- Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation.Journal of cachexia, sarcopenia and muscle · 2026Article
- Inflammation-Linked Muscle Atrophy in Limb Girdle Muscular Dystrophy R1 (LGMDR1): Insights into Disease Mechanisms.Current issues in molecular biology · 2026Article
- Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injury.Cell death discovery · 2026Article
- Fiber-type vulnerability and proteostasis reprogramming in skeletal muscle during pancreatic cancer cachexia.JCI insight · 2026Article
- Article
- The effects of tissue inflammation on cancer cachexia.Biochimica et biophysica acta. Molecular basis of disease · 2026Review
- Mechanisms of protein degradation in atrophying muscles: What have we learned during the past decade?The Journal of biological chemistry · 2026Review
- A Novel Mouse Model to Identify Antigen-Specific Immune Responses in Pancreatic Cancer Cachexia.Cancers · 2026Article
- NF-κB Signaling as a Central Driver of Cancer Cachexia.Cancers · 2026Review
- Cancer cachexia: molecular basis and therapeutic advances.Signal transduction and targeted therapy · 2026Review
- The Muscle-Liver Immunometabolic Axis in Liver Transplantation: A Decisive Role in Outcomes and Mechanisms.International journal of biological sciences · 2026Review
- Sex-specific mediating role of serum uric acid in the association between dietary diversity and muscle strength in urban community-dwelling older adults.Frontiers in public health · 2026Article
- Celebrating the 40-year milestone: NF-ĸB in oncoimmunity.Cancer letters · 2026Review
- GPR55 Inhibits Inflammatory Factor TNF-α-Mediated RhoA/ROCK2/IκBα/p65 Signaling Pathway to Alleviate Diabetic Cardiomyopathy in Rats.International journal of general medicine · 2026Article
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Authors and funding
25 authors.
Benjamin R PryceDepartment of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA.
Alexander OlesDepartment of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA.
Erin E TalbertDepartment of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Health and Human Physiology, and the Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.
Martin J RomeoHollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Silvia VaenaHollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Sudarshana SharmaDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Victoria SpadaforaDepartment of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA.
Lauren TolliverDepartment of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA.
David A MahviDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29403, USA.
Katherine A MorganDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29403, USA.
William P LancasterDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29403, USA.
Eryn BealDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29403, USA.
Natlie KorenDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29403, USA.
Bailey WattsDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29403, USA.
Morgan OverstreetDepartment of Surgery, Medical University of South Carolina, Charleston, SC 29403, USA.
Stefano BertoDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
Suganya SubramanianDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
Kubra CalisirDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Anna CrawfordHollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Brian NeelonHollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Michael C OstrowskiHollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Teresa A ZimmersDepartment of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Portland, Oregon Health Science University, Portland, OR 97239, USA.
James G TidballDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
David J WangDepartment of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA.
Denis C GuttridgeDepartment of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: guttridg@musc.edu.
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3MTranslational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J Lemasters · 2009 to 2026
$42.7MThe Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5MThe role of the macroenvironment in pancreatic cancer-induced cachexiaP01CA236778 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GUTTRIDGE, DENIS C · 2021 to 2025
$9.7MNF-kB Regulation of the Muscle Microenvironment in Cancer CachexiaR01AR072714 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GUTTRIDGE, DENIS C · 2020 to 2024
$2.3MManipulation of STAT3 Signaling for Muscle Preservation in Cancer CachexiaR01CA122596 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZIMMERS, TERESA A · 2010 to 2015
$1.6MPQB3: Mechanisms & Targeting of Sonic Hedgehog Signaling in Muscle Wasting of Cancer CachexiaR01CA194593 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI ZIMMERS, TERESA A · 2015 to 2018
$1.4MThe Extracellular Matrix in Muscle AtrophyR00AR071508 · NIAMS · UNIVERSITY OF IOWA · PI TALBERT, ERIN E · 2020 to 2022
$737kThe Extracellular Matrix in Muscle AtrophyK99AR071508 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TALBERT, ERIN E · 2018 to 2019
$189kElucidating the survival mechanisms of rhabdomyosarcomaF30CA265071 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI OLES, ALEXANDER R. · 2022 to 2023
$99kBLRD VA I01 BX004177CSRD VA I01 CX002046NCI NIH HHS F30 CA265071NCI NIH HHS P01 CA236778NCI NIH HHS P30 CA082709NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA122596NCI NIH HHS R01 CA194593NIAMS NIH HHS K99 AR071508NIAMS NIH HHS R00 AR071508NIAMS NIH HHS R01 AR072714NIGMS NIH HHS P20 GM148302
Abstract
Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its causality to cachexia by exploring skeletal muscle, whose atrophy strongly associates with poor outcomes. Using multiple mouse models and patient samples, we show that cachectic muscle is marked by enhanced innate immunity. Nuclear factor κB (NF-κB) activity in multiple cells, including satellite cells, myofibers, and fibro-adipogenic progenitors, promotes macrophage expansion equally derived from infiltrating monocytes and resident cells. Moreover, NF-κB-activated cells and macrophages undergo crosstalk; NF-κB
Indexed as
CachexiaInflammationMacrophagesMuscle, SkeletalNeoplasmsNF-kappa BAnimalsHumansMaleMiceMice, Inbred C57BLMuscular AtrophyNF-kappa Bcancer cachexiaCP: CancerCP: Immunologyfibro-adipogenic progenitorsmacrophagesmuscle progenitor cellsNF-κBpancreatic cancer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.