Evidence map›Paper›PMID 39475467›Full record

ArticleeLife2024

Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis.

Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Do Dinh Vinh, Artika P Nath, Joseph Donovan, Nguyen Thi Anh Thu, Dang Van Thanh, Nguyen Duc Bang, Dang Thi Minh Ha and 6 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A clinical practice guideline for tuberculous meningitis.The Lancet. Infectious diseases · 2026
    Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hoang Thanh Hai *Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.ORCID https://orcid.org/0000-0002-1809-5541
Le Thanh Hoang Nhat *Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Trinh Thi Bich TramOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Do Dinh VinhOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Artika P NathCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia.
Joseph DonovanOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Nguyen Thi Anh ThuOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Dang Van ThanhOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Nguyen Duc BangPham Ngoc Thanh Hospital, Ho Chi Minh City, Viet Nam.
Dang Thi Minh HaPham Ngoc Thanh Hospital, Ho Chi Minh City, Viet Nam.
Nguyen Hoan PhuOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Ho Dang Trung NghiaOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Le Hong VanOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Michael InouyeCambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia.ORCID https://orcid.org/0000-0001-9413-6520
Guy E ThwaitesOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.ORCID https://orcid.org/0000-0002-2858-2087
Nguyen Thuy Thuong ThuongOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.ORCID https://orcid.org/0000-0001-8733-692X

Funding

Systems Biology, Bioinformatics, & Data IntegrationU19AI162583 · NIAID · UNIVERSITY OF WASHINGTON · PI COX, JEFFERY S, HAWN, THOMAS R · 2021 to 2025
$13.0M
NIAID NIH HHS U19 AI162583Wellcome TrustWellcome Trust 10.35802/106680Wellcome Trust 10.35802/110179Wellcome Trust 10.35802/206724
6 · The paper itself

Abstract

Mortality and morbidity from tuberculous meningitis (TBM) are common, primarily due to inflammatory response to

Indexed as

Tuberculosis, MeningealAdultFemaleGene Expression ProfilingHIV InfectionsHumansMaleMiddle AgedMycobacterium tuberculosisTranscriptomeVietnamYoung Adulthumanimmunologyinfectious diseaseinflammationmicrobiologymortalitypathogenesisprognostictuberculous meningitiswhole blood RNA sequencing

Identifiers

PMID39475467
PMCPMC11524586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.