Activity and cryo-EM structure of the polymerase domain of the human norovirus ProPol precursor.
Alice M McSweeney, Alice-Roza Eruera, Geena M McKenzie-Goldsmith, James C Bouwer, Simon H J Brown, Louise A Stubbing, Jonathan G Hubert, Rinu Shrestha, Kevin J Sparrow, Margaret A Brimble and 5 more
Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Alice M McSweeney *Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID 0009-0009-8182-1081
Alice-Roza Eruera *Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Geena M McKenzie-GoldsmithDepartment of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
James C BouwerSchool of Chemistry and Molecular Bioscience, Molecular Horizons, and Australian Research Council Centre for Cryo-electron Microscopy of Membrane Proteins, University of Wollongong, Wollongong, New South Wales, Australia.
Simon H J BrownSchool of Chemistry and Molecular Bioscience, Molecular Horizons, and Australian Research Council Centre for Cryo-electron Microscopy of Membrane Proteins, University of Wollongong, Wollongong, New South Wales, Australia.
Louise A StubbingSchool of Chemical Sciences, The University of Auckland, Auckland, New Zealand.
Jonathan G HubertSchool of Chemical Sciences, The University of Auckland, Auckland, New Zealand.
Rinu ShresthaFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.
Kevin J SparrowFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.
Margaret A BrimbleSchool of Chemical Sciences, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-7086-4096
Lawrence D HarrisFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.ORCID 0000-0002-4214-1018
Gary B EvansFerrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand.ORCID 0000-0002-6973-2002
Mihnea BostinaDepartment of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID 0000-0003-3621-3772
Kurt L KrauseDepartment of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-3525-1112
Vernon K WardDepartment of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-8692-5116
Funding
Ministry of Business, Innovation and Employment (MBIE) UOOX1904Royal Society Te Apārangi (Royal Society of New Zealand) 21-UOO-003-CSG
6 · The paper itself
Abstract
Human norovirus (HuNV) is a leading cause of acute gastroenteritis worldwide with most infections caused by genogroup I and genogroup II (GII) viruses. Replication of HuNV generates both precursor and mature proteins during processing of the viral polyprotein that are essential to the viral lifecycle. One such precursor is protease-polymerase (ProPol), a multi-functional enzyme comprised of the norovirus protease and polymerase proteins. This work investigated HuNV ProPol by determining the
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Activity and cryo-EM structure of the polymerase domain of the human norovirus ProPol precursor. · full record | OpenQuestion