Evidence map›Paper›PMID 39475275›Full record

ArticleJournal of virology2024

Adeno-associated virus 9 (AAV9) viral proteins VP1, VP2, and membrane-associated accessory protein (MAAP) differentially influence

Sara K Powell, Thomas J McCown

Abstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
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  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sara K PowellDepartment of Pediatrics-Genetics and Metabolism, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-6585-9172
Thomas J McCownUniversity of North Carolina Gene Therapy Center, Chapel Hill, North Carolina, USA.ORCID 0009-0001-0127-4578

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
AAV capsid-promoter interactions determines CNS cell selective gene expression in vivoR01NS116019 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCCOWN, THOMAS J. · 2021 to 2025
$1.9M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 5R01NS116019NCI NIH HHS P30 CA016086NICHD NIH HHS P50 HD103573NINDS NIH HHS P30 NS045892NINDS NIH HHS R01 NS116019
6 · The paper itself

Abstract

Adeno-associated virus (AAV) is a IMPORTANCE: Recombinant adeno-associated viruses (AAVs) are used extensively in clinical gene therapy for treating a range of tissues and pathologies in humans. In particular, AAV9 occupies a prominent position in central nervous system (CNS) gene therapy given its central role in ongoing clinical trials and an FDA-approved therapeutic. Despite its widespread use, recent studies have identified unique roles for the AAV capsid in

Indexed as

Capsid ProteinsDependovirusGenetic VectorsPromoter Regions, GeneticTransgenesAnimalsCapsidGene ExpressionGenetic TherapyHumansNeuronsRatsTransduction, GeneticCapsid Proteinsadeno-associated viruscapsidheterologous gene expressionMAAPtransgeneVP1VP2

Identifiers

PMID39475275
PMCPMC11575147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.