Evidence map›Paper›PMID 39475240›Full record

ArticlemBio2024

High-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits.

Robeena Farzand, Mercy W Kimani, Evangelos Mourkas, Abdullahi Jama, Jack L Clark, Megan De Ste Croix, William M Monteith, Jay Lucidarme, Neil J Oldfield, David P J Turner and 4 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Rapid and recent evolution ofMicrobial genomics · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Robeena Farzand *Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Mercy W Kimani *Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Evangelos Mourkas *Department of Biology, University of Oxford, Oxford, United Kingdom.
Abdullahi JamaDepartment of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Jack L ClarkDepartment of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Megan De Ste CroixDepartment of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
William M MonteithDepartment of Biology, University of Oxford, Oxford, United Kingdom.
Jay LucidarmeMeningococcal Reference Unit, UK Health Security Agency, Manchester, United Kingdom.
Neil J OldfieldSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
David P J TurnerSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Ray BorrowMeningococcal Reference Unit, UK Health Security Agency, Manchester, United Kingdom.
Luisa Martinez-PomaresSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.ORCID 0000-0002-2331-127X
Samuel K SheppardDepartment of Biology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-6901-3203
Christopher D BaylissDepartment of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.ORCID 0000-0002-5564-2145

Funding

UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M01116X/1UKRI | Medical Research Council (MRC) MR/S009264/1Wellcome TrustWellcome Trust (WT) 218505/Z/19/Z
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) with binary or single phenotype data have successfully identified disease-associated genotypes and determinants of antimicrobial resistance. We describe a novel phenotype-to-genotype approach for a major bacterial pathogen that involves simultaneously testing for associations among multiple disease-related phenotypes and linkages between phenotypic variation and genetic determinants. High-throughput assays quantified variation among 163

Indexed as

GenotypeMeningococcal InfectionsNeisseria meningitidisPhenotypeCarrier StateGenetic VariationGenome-Wide Association StudyHigh-Throughput Screening AssaysHumansPolymorphism, Single Nucleotidegenotype-to-phenotypeGWASNeisseria meningitidispathogenesisphase variation

Identifiers

PMID39475240
PMCPMC11633189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.