Evidence map›Paper›PMID 39475231›Full record

ArticlemBio2024

The vitamin D receptor is essential for the replication of pseudorabies virus.

Lei Zeng, Shu-Yi Wang, Meng-Hua Du, Bei-Bei Chu, Sheng-Li Ming

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei Zeng *College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.
Shu-Yi Wang *College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.
Meng-Hua Du *College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.
Bei-Bei ChuCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.ORCID 0000-0003-2961-4754
Sheng-Li MingCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.ORCID 0000-0002-7505-6143

Funding

MOST | National Key Research and Development Program of China (NKPs) 2023YFD1801600
6 · The paper itself

Abstract

The vitamin D receptor (VDR) is a nuclear steroid receptor that regulates the expression of genes across various biological functions. However, the role of VDR in pseudorabies virus (PRV) infection has not yet been explored. We discovered that VDR positively influenced PRV proliferation because knockdown of VDR impaired PRV proliferation, whereas its overexpression promoted it. Additionally, we observed that PRV infection upregulated VDR transcription alongside 1,25-dihydroxyvitamin D3 (VD

Indexed as

Herpesvirus 1, SuidReceptors, CalcitriolVirus ReplicationAnimalsCalciumCell LineMechanistic Target of Rapamycin Complex 1Phosphatidylinositol 3-KinasesPseudorabiesSignal TransductionSwineCalciumMechanistic Target of Rapamycin Complex 1Phosphatidylinositol 3-KinasesReceptors, CalcitriolAMPK/mTORC1Ca2+lipid synthesisp53PI3K/AKT/mTORC1PRVVDR

Identifiers

PMID39475231
PMCPMC11633143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.