Evidence map›Paper›PMID 39474587›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2024

C1q Binding Ability for Prior Risk Assessment of Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.

Yuko Miwa, Kenta Iwasaki, Kenta Murotani, Manabu Okada, Takaharu Nagasaka, Yoshihiko Watarai, Asami Takeda, Masato Shizuku, Satoshi Ashimine, Kohei Ishiyama and 2 more

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Article in Transplant international : official journal of the European Society for Organ Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Diagnostic and predictive biomarkers of acute rejection after liver transplantation.International journal of surgery (London, England) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuko MiwaDepartment of Kidney Disease and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan.
Kenta IwasakiDepartment of Kidney Disease and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan.
Kenta MurotaniBiostatistics Center, Kurume University, Kurume, Japan.
Manabu OkadaDepartment of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan.
Takaharu NagasakaDepartment of Transplant Surgery, Toyohashi Municipal Hospital, Toyohashi, Japan.
Yoshihiko WataraiDepartment of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan.
Asami TakedaDepartment of Nephrology, Masuko Memorial Hospital, Nagoya, Japan.
Masato ShizukuDepartment of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan.
Satoshi AshimineDepartment of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan.
Kohei IshiyamaDepartment of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan.
Shoichi MaruyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takaaki KobayashiDepartment of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In ABO blood group incompatible kidney transplantation (ABO-I), potential issues on acute antibody-mediated rejection (ABMR) remain to be solved. This study aimed to assess the risk factors of acute ABMR using recipient- or donor-derived specimens. Quantitative analysis of A/B antigen expression was conducted in 104 donor kidney tissues (Kt), platelets (Plt), and red blood cells (RBC) by immunohistochemical staining or flow cytometry (FCM). ABO-I pre-transplant recipient serum samples (ABMR = 12, non-ABMR = 27) were extracted by propensity score matching. Anti-A antibody titers of IgM, IgG and IgG subclasses, and C1q binding ability (%) on antibody were measured using RBC-FCM. No association was observed between ABMR and A/B antigen expression levels in donor's Plt, RBC, or Kt. In recipient's sample, C1q-IgG binding ability was significantly higher in the ABMR group than in the non-ABMR group (C1q-IgG: 9.04% vs. 5.93%

Indexed as

ABO Blood-Group SystemBlood Group IncompatibilityComplement C1qGraft RejectionKidney TransplantationAdultAgedFemaleHumansImmunoglobulin GImmunoglobulin MIsoantibodiesMaleMiddle AgedRisk AssessmentRisk FactorsABO Blood-Group SystemComplement C1qImmunoglobulin GImmunoglobulin MIsoantibodiesA/B antigen expression levels of donor specimensABO-incompatible kidney transplantationacute antibody-mediated rejectionC1q binding abilityIgG subclasses

Identifiers

PMID39474587
PMCPMC11518703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.