ArticleEnvironment & health (Washington, D.C.)2023
Maternal Bisphenol B Exposure and Mammary Gland Development of Offspring: A Time-Series Analysis.
Article in Environment & health (Washington, D.C.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.Journal of xenobiotics · 2025Review
- Exploring the Antagonistic Effects of Bisphenols with Nonmonotonic Dose-Response Curves on the Estrogen Receptor.Environment & health (Washington, D.C.) · 2025Article
- In utero exposure to estrogenic bisphenol analogues increases mammary tissue stiffness.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Taurine protection attenuates bisphenol-A-induced behavioral, neurochemical, and histopathological alterations in male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Selective detection of food contaminants using engineered gallium-organic frameworks with MD and metadynamics simulations.Scientific reports · 2024Article
- Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives.Toxics · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer incidence has increased and become the world's most prevalent cancer, which is related to abnormal development of mammary glands and thought to be influenced by environment endocrine disruptors such as bisphenol A (BPA). However, whether its substitution, bisphenol B (BPB), has similar effects remains a concern. In the present study, a maternal exposure model of ICR mice combined time-series RNA-seq analysis was established to explore the underlying correlation among maternal BPB exposure (300 μg/kg body weight), mammary gland development, and long-term breast health in offspring. The results showed that BPB exposure disrupted hormonal homeostasis of the female offspring but did not affect the branch development of mammary glands in a time-dependent manner. However, at postnatal day 90 (PND90), BPB exposure resulted in duct dilatation, lobular hyperplasia, and inflammatory cell infiltration and increased the number of hormone receptor-expressing (HR
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Registered trials
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