Evidence map›Paper›PMID 39474479›Full record

ReviewChemical & biomedical imaging2024

Advances in Small-Molecule Fluorescent pH Probes for Monitoring Mitophagy.

Yurui Liu, Duoteng Zhang, Yunwei Qu, Fang Tang, Hui Wang, Aixiang Ding, Lin Li

Abstract readReview
In one paragraph

Review in Chemical & biomedical imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  8. Lysosome as a Chemical Reactor.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yurui LiuThe Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China.
Duoteng ZhangThe Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China.
Yunwei QuThe Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China.
Fang TangThe Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China.
Hui WangThe Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China.
Aixiang DingThe Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China.
Lin LiThe Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China.ORCID https://orcid.org/0000-0003-0426-6546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria play a crucial role in regulating cellular energy homeostasis and cell death, making them essential organelles. Maintaining proper cellular functions relies on the removal of damaged mitochondria through a process called mitophagy. Mitophagy is associated with changes in the pH value and has implications for numerous diseases. To effectively monitor mitophagy, fluorescent probes that exhibit high selectivity and sensitivity based on pH detection have emerged as powerful tools. In this review, we present recent advancements in the monitoring of mitophagy using small-molecule fluorescence pH probes. We focus on various sensing mechanisms employed by these probes, including intramolecular charge transfer (ICT), fluorescence resonance energy transfer (FRET), through bond energy transfer (TBET), and photoelectron transfer (PET). Additionally, we discuss disease models used for studying mitophagy and summarize the design requirements for small-molecule fluorescent pH probes suitable for monitoring the mitophagy process. Lastly, we highlight the remaining challenges in this field and propose potential directions for the future development of mitophagy probes.

Identifiers

PMID39474479
PMCPMC11503929

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.