ArticleEnvironment & health (Washington, D.C.)2024
Effect of Elevated Temperatures on Inflammatory Cytokine Release: An
Article in Environment & health (Washington, D.C.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- AHR: The Overlooked Mediator in SkincareBridging Environmental Sensing and Skin Physiology.Environment & health (Washington, D.C.) · 2026Review
- Postoperative Risk and Climate Exposure: A Retrospective Study of Incisional Glaucoma Surgery Outcomes.Translational vision science & technology · 2026Article
- Nationwide Study of the Association between Temperature Variability and Sleep Apnea, and the Modifying Role of Air Pollution, in a Moderate-to-Severe Risk OSA Population.Environment & health (Washington, D.C.) · 2026Article
- Excess risk of heat-related hospitalization associated with temperature and PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026Article
- Effects of meteorological variability on the burden of musculoskeletal disorders among people aged 55 and above in the United States: a secondary analysis of the Global Burden of Disease Study 2021.Frontiers in public health · 2026Article
- Fish Skin Mucus Vitellogenin as a Noninvasive, Sensitive Biomarker for Aquatic Xenoestrogens.Environment & health (Washington, D.C.) · 2025Article
- The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies.Therapeutic advances in infectious diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extreme high temperatures in the summer have become a global concern, and their risks to the inflammatory system have been largely unknown. Here we appraised the exposure risks of summer heatwaves by comparing the sera cytokine levels in healthy individuals under high and normal temperatures. In addition, we established a cell model with a 1.5 °C temperature increase to investigate the regulatory mechanisms of temperature-related cytokines. Our results suggest that elevated temperatures enhance the release of interleukin-6 (IL-6) and interleukin-8 (IL-8) via the aryl hydrocarbon receptor (AhR) pathway and augment the pro-inflammatory effects of other factors. This suggests that we may have underestimated the impact of high temperatures on the health of individuals beyond just mortality rates. Moreover, seemingly minor temperature increases of just 1.5 °C can still pose a challenge to cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.