Evidence map›Paper›PMID 39474391›Full record

ArticleWorld journal of psychiatry2024

Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression.

Yi Cheng, Li-Jing Lv, Yu Cui, Xiao-Mei Han, Yan Zhang, Cai-Xia Hu

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Article in World journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi ChengDepartment of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
Li-Jing LvDepartment of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
Yu CuiDepartment of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
Xiao-Mei HanDepartment of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
Yan ZhangDepartment of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
Cai-Xia HuDepartment of Dermatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China. 48201485@hebmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAndrogenetic alopecia (AGA) is a common form of hair loss that can be influenced by psychological factors.

aimTo investigate the impact of mental stress on neurotrophic factors in patients with AGA and correlate the findings with the progression of AGA.

methodsA total of 120 patients with AGA were analyzed in this study, which were divided into a non-stress group (

resultsThis study revealed significantly higher cortisol levels throughout the day in the stress group than in the non-stress group. The stress group exhibited lower levels of nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor and higher expression levels of neurotrophin (NT)-3 and NT-4 than the non-stress group. Hair parameters indicated lower hair diameter, decreased hair density, and more severe AGA grading in the stress group, whereas follicle count and terminal/vellus hair ratio showed no significant differences between the two groups. After 1 year of treatment with 5% minoxidil, efficacy was observed to be lower but AGA progression was notably more pronounced in the stress group than in the non-stress group. Disease progression was positively correlated with high stress and NT-4 levels.

conclusionThis study provides compelling evidence of the influence of mental stress on neurotrophic factors and its correlation with the progression of AGA. The findings underscore the need for a comprehensive approach to the management of AGA that considers the physiological and psychosocial aspects. Further research is warranted to validate the findings and explore targeted therapeutic interventions for individuals with stress-related AGA.

Indexed as

Androgenetic alopeciaMental stressNeurotrophic factorsProgression

Identifiers

PMID39474391
PMCPMC11514570

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