ArticleWorld journal of psychiatry2024
Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder.
Article in World journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association between anxious-depression and cognitive function in community-dwelling older adults: a latent class analysis.Frontiers in public health · 2026Article
- Cognitive impairment based on computerized testing among patients with major depressive disorder after remission.Frontiers in human neuroscience · 2026Article
- Resilience displays similar associative patterns with academic achievement regardless of the personality and mental health profile of future teachers.BMC psychology · 2025Article
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18 authors.
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Abstract
backgroundSymptoms of depression and comorbid anxiety are known risk factors for cognitive impairment in major depressive disorder (MDD). Understanding their relationships is crucial for developing targeted interventions to mitigate cognitive impairments in MDD patients. We expect that the severity of sleep disturbances and other depressive symptoms will be positively correlated with the degree of cognitive impairments. We also hypothesize that anxiety symptoms, especially psychic anxiety, is a key factor in predicting cognitive performance in MDD patients and may indirectly contribute to cognitive impairment by affecting sleep disturbances and other potential factors.
aimTo determine which dimension of the depressive and anxiety symptoms predicts cognitive impairment during a depressive episode.
methodsA comprehensive neurocognitive test battery assessed executive function, attention, processing speed, and memory in 162 medication-free MDD patients and 142 matched healthy controls. The 24-item Hamilton Depression Rating Scale was used to assess depressive symptoms, and the 14-item Hamilton Anxiety Scale was used to assess anxiety symptoms. Linear regression analyses and mediation analyses were conducted to evaluate the impact of depressive and anxiety symptoms, as well as their interactions, on cognitive impairments.
resultsAmong the depressive symptoms, sleep disturbances were associated with poorer executive function (
conclusionSleep disturbances may be a key predictor of poorer executive function, lower processing speed, and memory loss, while PR is crucial for lower processing speed during a depressive episode. Psychic anxiety contributes to all aspects of cognitive impairments, mediated by sleep disturbances and PR.
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