Evidence map›Paper›PMID 39474340›Full record

ArticleHealth science reports2024

From photonic technologies to microfluidics-A review on the techniques which revolutionize liquid biopsy, opening a new era in cancer therapy.

Subham Sarkar, Soubhagya Ghosh, Samraggi Chakraborty, Jenifer Rajak, Ekanansha R Chowdhury, Arup K Mitra, Ajoy Kumer, Bikram Dhara

Abstract read
In one paragraph

Article in Health science reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Subham SarkarPostgraduate and Research Department of Biotechnology St. Xavier's College (Autonomous) Kolkata India.
Soubhagya GhoshPostgraduate and Research Department of Microbiology St. Xavier's College (Autonomous) Kolkata India.
Samraggi ChakrabortyS.N. Pradhan Centre for Neuroscience, Taraknath Palit Siksha Prangan University of Calcutta Kolkata India.
Jenifer RajakPostgraduate and Research Department of Microbiology St. Xavier's College (Autonomous) Kolkata India.
Ekanansha R ChowdhuryDepartment of Biotechnology University of Engineering and Management Kolkata India.
Arup K MitraPostgraduate and Research Department of Microbiology St. Xavier's College (Autonomous) Kolkata India.
Ajoy KumerDepartment of Chemistry IUBAT-International University of Business Agriculture & Technology Dhaka Bangladesh.
Bikram DharaCentre for Global Health Research Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital Chennai India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Cancer therapy is one of the most researched upon medical field in the world. Non invasive technologies such as liquid biopsy are gaining more importance in cancer therapy because of their manifold advantages over traditional invasive biopsy methods. Liquid biopsy is used to analyze nucleic acids such as ctDNA, cfDNA and RNA, cellular and subcellular components such as proteins, extracellular vesicles and circulating tumor cells in various biological fluids such as blood, urine, cerebrospinal fluid, pleural fluid and ascites fluid for diagnosis of cancer. Methods: Liquid biopsy has a wide range of applications such as assessment of residual diseases and tumors which cannot be biopsied easily and prediction of CAR-T response and response to immune checkpoint inhibitors. It can also be used to know the efficacy of cancer drugs in a patient by analyzing multiple samples. Liquid biopsy is becoming more popular as it allows biopsy of those samples in which solid tumor biopsies are challenging or impracticable. Techniques and Results: To achieve comprehensive insight on the status of cancer in a patient, various cutting edge liquid biopsy techniques have been developed. Microfluidics and photonic technologies, along with PCR, next generation sequencing, advanced and innovative molecular and cell biology approaches and imaging techniques have expanded the domain of liquid biopsy and elevated the accuracy of liquid biopsy results. Conclusion: This review discusses about the contributions of some widely used methods along with microfluidics and photonic technologies in detection of cancer biomarkers by liquid biopsy.

Indexed as

cancer biomarkersliquid biopsymicrofluidicsphotonic technologies

Identifiers

PMID39474340
PMCPMC11518885

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.