Evidence map›Paper›PMID 39474240›Full record

ArticleMedical cannabis and cannabinoids

Development and in vitro Evaluation of Cannabidiol Mucoadhesive Buccal Film Formulations Using Hot-Melt Extrusion Technology.

Iman E Taha, Mahmsoud A ElSohly, Mohamed M Radwan, Sundus Omari, Michael A Repka, Eman A Ashour

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Article in Medical cannabis and cannabinoids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iman E TahaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS, USA.
Mahmsoud A ElSohlyDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS, USA.
Mohamed M RadwanNational Center for Natural Product Research, University of Mississippi, University, MS, USA.
Sundus OmariDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS, USA.
Michael A RepkaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS, USA.
Eman A AshourDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cannabidiol (CBD) has sparked considerable interest because of its wide range of pharmacological uses and the fact that it does not induce psychoactive effects. CBD formulation development presents significant challenges due to its limited water solubility and susceptibility to first-pass metabolism, both of which restrict its overall bioavailability. The current research aimed to use hot-melt extrusion (HME) technology to develop mucoadhesive buccal films to improve CBD solubility and reduce first-pass metabolism. Methods: Five formulations containing 10% w/w CBD were extruded using a counter-rotating twin-screw extruder (Haake Minilab II, Thermo Fisher Scientific). Different characterization studies were conducted on the developed formulations. Results: Differential scanning calorimetry (DSC) revealed that the CBD endothermic peak disappeared in some of the developed films, indicating that CBD was converted from crystalline to amorphous form. A bio-adhesion study showed that the formulations containing Carbopol Conclusion: The current study demonstrates that HME was successfully used as an approach to develop CBD mucoadhesive buccal films and CBD solubility was enhanced.

Indexed as

CannabidiolHot-melt extrusionMucoadhesive buccal filmPolymeric carrierSolubility enhancement

Identifiers

PMID39474240
PMCPMC11521429

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.