ArticleiScience2024
Is political ideology correlated with brain structure? A preregistered replication.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The Amygdala and Politics.Brain sciences · 2026Review
- Fight, Flight, or Vote Right? A Systematic Review of Threat Sensitivity in Political Conservatism.Brain sciences · 2025Review
- Effects of focal brain damage on political behaviour across different political ideologies.Brain : a journal of neurology · 2025Article
- Cognitive-Affective Dynamics of Political Attitude Polarization: EEG-Based Behavioral Evidence from a COVID-19 Vaccine Mandate Task.Behavioral sciences (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We revisit the hypotheses that conservatism positively correlates with amygdala and negatively with anterior cingulate cortex (ACC) gray matter volume.Using diverse measures of ideology and a large and representative sample (Amsterdam Open MRI Collection [n = 928]), we replicate a small positive relationship between amygdala volume and conservatism. However, we fail to find consistent evidence in support of the ideology-ACC volume link. Using a split-sample strategy,we conducted exploratory whole-brain analyses on half the data, preregistered the findings, and then conducted subsequent confirmatory tests that additionally highlight weak, positive associations between the right fusiform gyri and conservatism. This is the largest preregistered replication study in the context of political neuroscience. By using Dutch as opposed to British or American data, we also extend the amygdala-conservatism link to a multiparty, multidimensional political context. We discuss the implications for future investigations of the neural substrates of ideology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.