Evidence map›Paper›PMID 39474042›Full record

ArticleTurkish journal of biology = Turk biyoloji dergisi2024

Pterostilbene suppresses head and neck cancer cell proliferation via induction of apoptosis.

Talih Özdaş, Sibel Özdaş, İpek Canatar, Erdem Kaypak

Abstract read
In one paragraph

Article in Turkish journal of biology = Turk biyoloji dergisi, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Talih ÖzdaşDepartment of ENT, Adana City Training and Research Hospital, Health Science University, Adana, Turkiye.ORCID https://orcid.org/0000-0003-3651-1892
Sibel ÖzdaşDepartment of Bioengineering, Faculty of Engineering Sciences, Adana Alparslan Türkeş Science and Technology University, Adana, Turkiye.ORCID https://orcid.org/0000-0003-4610-2785
İpek CanatarDepartment of Bioengineering, Faculty of Engineering Sciences, Adana Alparslan Türkeş Science and Technology University, Adana, Turkiye.ORCID https://orcid.org/0000-0001-9448-8112
Erdem KaypakDepartment of ENT, Adana City Training and Research Hospital, Health Science University, Adana, Turkiye.ORCID https://orcid.org/0000-0002-8444-6530

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: Head and neck cancer (HNC) is one of the most prevalent causes of death worldwide, and so discovering anticancer agents for its treatment is very important. Pterostilbene (PS) is a trans-stilbene reported to be beneficial in managing various cancers. The objective of the study was to evaluate the cytotoxic, antiproliferative, proapoptotic, and antimigrative effect of PS on HEp-2, SCC-90, SCC-9, FaDu, and Detroit-551 cell lines. Materials and methods: MTT and live/dead assays were employed to assess cell viability, while a cell migration test was performed to evaluate wound healing capacity. The mRNA, protein, and intracellular expression levels of Results: The results revealed that PS displayed cytotoxic, antiproliferative activity in a dose-dependent manner in HNC cells by upregulating Conclusion: The present study provides proof that PS has the prospective to be improved as an attractive anticancer agent against HNC following advanced studies.

Indexed as

anticancerapoptosiscytotoxicityHead and neck cancerpterostilbene

Identifiers

PMID39474042
PMCPMC11518375

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.