ArticlePrecision chemistry2024
Synergy of Prediction Rule and Total Synthesis in Solving the Stereochemical Puzzle of Valactamides.
Article in Precision chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Decoding Lusichelins A-E: An In-Depth Look at the Metallophores ofJournal of natural products · 2025Article
- Total Syntheses and Stereochemical Assignment of Acremolides A and B.Molecules (Basel, Switzerland) · 2024Article
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Authors and funding
5 authors.
Funding
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Abstract
Natural products with diverse functional groups and stereogenic centers have inspired therapeutics and underpin the modern drug discovery process. Their three-dimensional molecular structures need to be unambiguously determined in order to be realized as clinical candidates or to achieve further activity-guided structural optimization. Although recent advances in spectroscopic methods have made it possible for researchers to determine the structures of microgram samples of complex natural products, there is no universally accepted method for determining the relative and absolute configuration of a naturally occurring compound. We report the determination of the full stereostructure of valactamide A, an eight-stereogenic-center-containing fungal metabolite by the synergy of prediction rule-guided analysis and chemical synthesis. The expedient total synthesis resulted in unambiguous verification of the predicted stereochemistry for valactamide A.
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Registered trials
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