Evidence map›Paper›PMID 39473989›Full record

ArticleChemical & biomedical imaging2024

An Activatable Semiconducting Nanoprobe for Early and Accurate Diagnosis of Liver Injury.

Fei Li, Shaobin Wu, Keyang Li, Jun Zhu, Shasha He, Huayu Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Organic Semiconducting Polymers for Cancer Sonodynamic Immunotherapy.Polymer science & technology (Washington, D.C.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fei LiState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Shaobin WuState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Keyang LiState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Jun ZhuState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Shasha HeState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.ORCID https://orcid.org/0000-0003-0079-8625
Huayu TianState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.ORCID https://orcid.org/0000-0002-2482-3744

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver injury, caused by factors like viral hepatitis and drug overdose, poses a significant health risk, with current diagnostic methods lacking specificity, increasing the need for more precise molecular imaging techniques. Herein, we present an activatable semiconducting liver injury reporter (SLIR) for early and accurate diagnosis of liver injury. The SLIR, which is composed of semiconducting polymers with an electron-withdrawing quenching segment, remains nonfluorescent until it encounters biothiols such as cysteine in the liver. SLIR accumulates efficiently in the liver and respond rapidly to biothiols, allowing accurate and early detection of liver damage. The recovery of SLIR fluorescence negatively reflects the dynamics of oxidative stress in the liver and provides information on the severity of tissue damage. Thus, the specificity of SLIR, the fast response, and the efficient targeting of the liver make it a promising tool for the precise diagnosis of liver damage at an early stage.

Identifiers

PMID39473989
PMCPMC11503912

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.