Evidence map›Paper›PMID 39473973›Full record

ArticleiScience2024

Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity.

Gabriel Ruiz-Romero, María Dolores Berdún, Mark Hochstrasser, Silvia Salas-Pino, Rafael R Daga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gabriel Ruiz-RomeroCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Departamento de Biología Molecular e Ingeniería Bioquímica, Carretera de Utrera, km1 41013 Seville, Spain.
María Dolores BerdúnCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Departamento de Biología Molecular e Ingeniería Bioquímica, Carretera de Utrera, km1 41013 Seville, Spain.
Mark HochstrasserDepartment of Molecular Biophysics & Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.
Silvia Salas-PinoCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Departamento de Biología Molecular e Ingeniería Bioquímica, Carretera de Utrera, km1 41013 Seville, Spain.
Rafael R DagaCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Departamento de Biología Molecular e Ingeniería Bioquímica, Carretera de Utrera, km1 41013 Seville, Spain.

Funding

Mechanisms of Cell Regulation and Manipulation by the Ubiquitin SystemR35GM136325 · NIGMS · YALE UNIVERSITY · PI Mark W Hochstrasser · 2020 to 2026
$6.5M
NIGMS NIH HHS R35 GM136325
6 · The paper itself

Abstract

In addition to the degradation of cell-cycle proteins, short-lived, damaged, or unfolded proteins are constantly cleared from cells by the proteasome. During proliferation, the proteasome localizes to the nucleus and cytoplasm; however, the functional relevance of this compartmentalization remains unclear. Here, we show that folding stress increases 26S/30S proteasome activity, which correlates with the upregulation of Ump1, a chaperone involved in 20S assembly. Conversely,

Indexed as

Functional aspects of cell biologyMolecular biologyOrganizational aspects of cell biology

Identifiers

PMID39473973
PMCPMC11513537

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.