Evidence map›Paper›PMID 39473886›Full record

ArticleEnvironment & health (Washington, D.C.)2024

Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease: A Matched Case-Control Study in China.

Xuejie Chen, Wenya Liu, Yangjie Liao, Xin Xiang, Yue Yang, Li Tian, Xiang Gao, Qian Cao, Hong Guo, Kang Chao and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xuejie ChenDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Wenya LiuHunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Yangjie LiaoDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Xin XiangDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Yue YangHunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Li TianDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Xiang GaoDepartment of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510510, China.
Qian CaoDepartment of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310018, China.
Hong GuoDepartment of Gastroenterology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 401121, China.
Kang ChaoDepartment of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510510, China.
Fengmei SongHunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Rongbei LiuDepartment of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310018, China.
Ying LiHealth Management Center, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Shuyu YeDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Jiangang WangHealth Management Center, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Fei YangHunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.ORCID https://orcid.org/0000-0001-5687-0556
Xiaoyan WangDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, 410013, China.ORCID https://orcid.org/0000-0002-7281-1078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microcystin-LR (MC-LR), the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms, has been linked to gastrointestinal toxicity. Therefore, we conducted a case-control study across four regions in China to investigate this relationship. Inflammatory bowel disease (IBD) cases (219) were matched with healthy controls (438) based on age and gender and conditional logistic regression models and Restricted cubic splines were used to evaluate the association between MC-LR exposure and IBD risk. We used quantitative real-time polymerase chain reaction to measure the expression levels of inflammatory factors. The levels of protein expression in the colorectum were determined using Western blotting (WB). Compared to the lowest quartile of serum MC-LR levels, the adjusted odds ratios and 95% confidence intervals (CI) for the highest quartiles of serum MC-LR levels were 5.51 (2.70, 11.21). The RCS was shown the association between serum MC-LR levels and IBD risk was nonlinear (

Identifiers

PMID39473886
PMCPMC11503794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.