ArticleEnvironment & health (Washington, D.C.)2024
Exposure Patterns of Multiple Pesticides and Urinary Alterations of Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) among Pregnant Women.
Article in Environment & health (Washington, D.C.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Environmental exposure to pesticides is widespread and commonly occurs in mixtures, and pregnant women are particularly concerned. Trimethylamine N-oxide (TMAO), a dietary-derived catabolite linked to cardiometabolic disease, may be influenced by pesticide exposure. However, limited knowledge exists regarding the associations, and studies have primarily been restricted to single pesticides. To address this gap, we examined the associations of pesticide exposure with urinary TMA, TMAO, and TMAO-to-TMA ratio among 1067 pregnant women residing in a rural area. Latent class analysis (LCA) was applied to identify distinct patterns of pesticide exposure based on urinary metabolite concentrations. Multiple linear regression (MLR) models and Bayesian kernel machine regression (BKMR) models were employed to estimate the effects of single pesticides, exposure patterns, and combined exposure. Four distinct pesticide exposure patterns were identified. Higher concentrations of pesticide metabolites were found to be associated with increased urinary TMAO levels (β: 0.043 to 0.254,
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