ArticleChemical & biomedical imaging2024
Estimation of Medium Depolarization Index with Noise Immunity in Catheter-Based PS-OCT toward Vascular Plaques Detection.
Article in Chemical & biomedical imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Local Birefringence Imaging by Similar Mueller Matrix Averaging Method in Catheter-Based Polarization-Sensitive Optical Coherence Tomography.Chemical & biomedical imaging · 2026Article
- Application of Nanomaterials in Early Imaging and Advanced Treatment of Atherosclerosis.Chemical & biomedical imaging · 2025Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medium depolarization imaging by catheter-based polarization-sensitive optical coherence tomography (PS-OCT) can provide valuable insight into significant features of lipid, macrophages, and cholesterol crystals in atherosclerotic vulnerable plaques. In this paper, we demonstrate a method to achieve an accurate estimation of the medium depolarization index (EMDI) with noise immunity in catheter-based PS-OCT. EMDI is calculated by an iterative approximation based on Lu-Chipman matrix decomposition and Frobenius norm judgment of incoherent averaging of Mueller matrices. Monte Carlo simulation results verify that the medium depolarization measurement by EMDI is 3.3 times more accurate compared with those of the depolarization index (DI) and degree of polarization uniformity (DOPU). In experiments, we design a microsphere suspension with various concentrations and measure EMDI under different additive noise. Consistently, the measurement accuracy by EMDI is increased 2.85 times compared to those by DI and DOPU. For vascular plaques detection, we use protein and cholesterol gel as plaque phantoms. Based on PS-OCT images of plaque phantom in vitro and in ex vivo porcine coronary artery, the recognition rate of plaque by EMDI is 2.99 to 4.65 times higher than those by DI and DOPU evaluated by spatial response of the Laplacian operator (SRLO).
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Registered trials
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