ReviewCureus2024
The Evolution of Phage Therapy: A Comprehensive Review of Current Applications and Future Innovations.
Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Gut Microbiota Alterations in People Living With HIV: Dysbiosis, Immune Dysfunction and Therapeutic Perspectives.Reviews in medical virology · 2026Review
- Isolation and characterization of two phages infectingThe Journal of general virology · 2026Article
- Cell-free synthesis and characterization of Salmonella, Escherichia coli, and Shigella-specific bacteriophages.Microbial cell factories · 2026Article
- Characterization of novel phage Henuyfy11N: a potential therapeutic agent against extended-spectrum β-lactamase (ESBL)-producingMicrobiology spectrum · 2026Article
- A qPCR-Based Screening Platform for Exploratory Assessment of Phage Training Outcomes inViruses · 2026Article
- Phage Therapy in Combating Multidrug-Resistant Gram-Negative Pathogens: A Scoping Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Effect of bacteriophages on growth performance and health indicators in broiler chickens in the absence of bacterial challenge - A review.Veterinarni medicina · 2026Review
- Phage Therapy in Plant Disease Management: 110 Years of History, Current Challenges, and Future Trends.Plants (Basel, Switzerland) · 2026Review
- Phage-cocktail-based biocontrol of multidrug-resistant Klebsiella pneumoniae both in vitro and in vivo.Archives of virology · 2026Article
- Phage enabled precision drug delivery: dual function platforms for therapeutics and genetic cargo transport.Frontiers in microbiology · 2026Review
- Bacteriophage pharmacodynamics studied in anJAC-antimicrobial resistance · 2025Article
- Advances in combating antimicrobial resistance in MRSA: a comprehensive review on nanotechnology and phage therapy.Antonie van Leeuwenhoek · 2025Review
- Role of the Virome in Vaccine-Induced Immunization.Vaccines · 2025Review
- Exploration of Providers' Perceptions and Attitudes Toward Phage Therapy and Intentions for Future Adoption as an Alternative to Traditional Antibiotics in the US-A Cross-Sectional Study.International journal of environmental research and public health · 2025Article
- Phage Therapy in Managing Multidrug-Resistant (MDR) Infections in Cancer Therapy: Innovations, Complications, and Future Directions.Pharmaceutics · 2025Review
- Unconventional Therapies in Periprosthetic Joint Infections: Prevention and Treatment: A Narrative Review.Journal of clinical medicine · 2025Review
- The gut microbiome as a major source of drug-resistant infections: emerging strategies to decolonize and target the gut reservoir.Frontiers in cellular and infection microbiology · 2025Review
- Advancements in alternative approaches to address antimicrobial resistance in bacterial pneumonia: a comprehensive review.Frontiers in microbiology · 2025Review
- Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies.Frontiers in microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phage therapy, using bacteriophages to target and destroy bacteria, has evolved significantly from its early 20th-century inception to its modern resurgence as a promising alternative to antibiotics. This review explores the historical development of phage therapy, detailing its initial successes, subsequent decline with the rise of antibiotics, and recent revival in response to increasing antibiotic resistance. We examine the fundamental mechanisms of phage therapy, including the specificity of phages for bacterial targets and their ability to combat resistant strains. Current applications are discussed, highlighting the use of phage therapy in treating chronic infections, personalizing treatment strategies, and its role in veterinary and food safety contexts. Innovations in phage therapy, driven by advancements in genetic engineering and synthetic biology, are also reviewed, showcasing the development of engineered phages, phage libraries, and novel delivery systems. Despite its potential, phage therapy faces challenges such as regulatory hurdles, safety concerns, and issues related to bacterial resistance to phages. The review underscores the need for ongoing research and clinical trials to address these challenges and to integrate phage therapy into modern treatment paradigms. By offering a detailed overview of the evolution, current status, and future directions of phage therapy, this review aims to highlight its potential as a crucial component in the fight against antibiotic-resistant infections and to inform future research efforts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.