Evidence map›Paper›PMID 39473634›Full record

ArticleInternational journal of general medicine2024

Role of Biomarkers Diagnostic Tools in Patients with COVID-19: Stratification Made Easy.

Ahmed Abdallah Salman, Heba Mohamed Abdallah, Sami Eldahdouh, Sally Waheed Elkhadry, Samah Mohamed Awad, Ghada M K Gaballah, Eman Kamal Awaad, Mohammed Gaber Saad, Ahmed E Taha, Nahla K Gaballa

Abstract read
In one paragraph

Article in International journal of general medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmed Abdallah SalmanInternal Medicine Department, Faculty of medicine, Cairo University, Cairo, Egypt.ORCID 0000-0003-0026-0841
Heba Mohamed AbdallahDepartment of Clinical Pathology, National Liver Institute, Menoufia University, Shebin Elkom, Egypt.
Sami EldahdouhDepartment of Chest Diseases, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
Sally Waheed ElkhadryDepartment of Epidemiology and Community Medicine, National Liver Institute, Menoufia University, Shebin Elkom, Egypt.ORCID 0000-0001-9305-3045
Samah Mohamed AwadClinical Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shebin Elkom, Egypt.
Ghada M K GaballahMedical Biochemistry Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
Eman Kamal AwaadDepartment of Anesthesiology and Intensive Care, National Liver Institute, Menoufia University, Shebin Elkom, Egypt.
Mohammed Gaber SaadDepartment of Anesthesiology and Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID 0009-0006-4244-9377
Ahmed E TahaDepartment of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Nahla K GaballaDepartment of Anesthesiology and Intensive Care, National Liver Institute, Menoufia University, Shebin Elkom, Egypt.ORCID 0009-0006-0435-8829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: In coronavirus disease 2019 (COVID-19) patients, several serum biomarkers have been identified. Upon intensive care unit (ICU) admission, these laboratory markers become more crucial to distinguish between patients with severe cases of COVID-19. It might assist doctors in predicting the course of illnesses and treating patients appropriately. This work was to investigate the role of biomarkers in patients with COVID-19 classification admitted to the hospital and identified by reverse transcription polymerase chain reaction (RT-PCR). Methods: Peripheral blood sample was taken from COVID-19 cases isolated on admission to determine C-reactive protein (CRP), D-dimer, Fibrinogen, neutrophil-lymphocyte ratio (NLR), leukocytes CRP ratio (LeCR), lymphocyte-CRP ratio (LCR), interleukin-6 (IL6), leukocytes interleukin 6 ratio (LeIL6), systemic inflammatory index (SII), platelet-to-lymphocyte ratio (PLR), and tissue plasminogen activator inhibitor one (tPAI-1). Follow-up for IL6, Ferritin, D-dimer, and tPAI-1 were determined on the 3 Results: Comparisons of severity revealed that hypertension, chronic obstructive pulmonary disease (COPD), and Ischemia were major risk factors in COVID-19 patients. There was a statistically significant difference between the test groups for fibrinogen (p < 0.000), IL6 (p < 0.009), LeCR (p < 0.006), and LCR (p < 0.011). Conclusion: Based on laboratory test findings at the time of ICU admission, we can distinguish severe cases of COVID-19.

Indexed as

COVID-19intensive care unitrisk factorsRT- PCRserum biomarkers

Identifiers

PMID39473634
PMCPMC11520913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.