ArticleChemical & biomedical imaging2023
Electrochemiluminescence Imaging of Cellular Contact Guidance on Microfabricated Substrates.
Article in Chemical & biomedical imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Four-Dimensional Electrochemiluminescence Microscopy Enables Depth-Resolved Imaging of Single, Living Spheroids.Angewandte Chemie (International ed. in English) · 2026Article
- Dual-Enhanced Electrochemiluminescence Imaging on a Monolayer Film of Nanoreactors for Probing Cell-Matrix Interaction.Chemical & biomedical imaging · 2026Article
- Spatiotemporal and Digital Electrochemiluminescence Imaging for Intelligent Quantitative Biosensing.Chemical & biomedical imaging · 2026Review
- Spatial Visualization of Secreted Lysyl Oxidase Activity from Single Living Cells via Label-Free Electrochemiluminescence Microscopy.Chemical & biomedical imaging · 2026Article
- Picosecond laser-engineered osteon-inspired concentric micropatterns on titanium implants regulate cellular behaviour to facilitate osseointegration.Materials today. Bio · 2026Article
- Bright Circularly Polarized Electrochemiluminescence from Heterobinuclear IrAngewandte Chemie (International ed. in English) · 2026Article
- Recent advances in electrochemiluminescence sensing for in vitro cell analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- Electrochemiluminescent imaging of a NADH-based enzymatic reaction confined within giant liposomes.Analytical and bioanalytical chemistry · 2024Article
- Microtopography-Induced Nuclear Deformation Triggers Chromatin Reorganization and Cytoskeleton Remodeling.Chemical & biomedical imaging · 2024Article
- Complex electrochemiluminescence patterns shaped by hydrodynamics at a rotating bipolar electrode.Chemical science · 2024Article
- Infrared photoinduced electrochemiluminescence microscopy of single cells.Chemical science · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells tend to align and move by following anisotropic topographical cues, namely the phenomenon known as contact guidance-an essential step in cell alignment, adhesion, and migration. The effect of topographical cues on individual cells has been investigated extensively, but that on cell aggregates still remains to be fully understood. Considering the high surface sensitivity of electrochemiluminescence (ECL) microscopy, it was used in this work to explore the impact of surface topography on cell behaviors. First, we studied the variations of cell-matrix adhesions of cells cultured on different topographical features. Both fibroblast-like and epithelial cells plated on microgrooved electrodes exhibited obvious contact guidance behavior. Then, the effect of surface topography on cellular collective migration was investigated. Topographic cues would be a barrier for cell migration if the orientation of microgrooves was perpendicular to the direction of migration; otherwise, it would be a helper. Finally, it was found that relaxation of cytoskeleton contractility or reduction in adhesion density could weaken the directed migration of leading cells, because the alteration of migration directionality was retarded. In contrast, such interactions were lost on the contact guidance response of follower cells, as they still aligned by following the topographic cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.