GuidelineAllergy2025
EAACI guidelines on the management of IgE-mediated food allergy.
Registry-linked trialAbstract readPractice Guideline
In one paragraph
Guideline in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07764159 (An Open-Label, Multicenter, Randomized Clinical Trial Evaluating the Efficacy and Safety of Oral Multi-Food Immunotherapy With Peanut and Tree Nuts Protein Mixtures), which is not on this map. Cited by 66 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open-Label, Multicenter, Randomized Clinical Trial Evaluating the Efficacy and Safety of Oral Multi-Food Immunotherapy With Peanut and Tree Nuts Protein Mixtures
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- From systemic immune dysregulation to oral disease: evidence linking food allergies and oral manifestations- a systematic review.BMC oral health · 2026Pooled it
- Guideline
- Safety of a novel oral immunotherapy approach in preschool children with single and multiple food allergies.Frontiers in allergy · 2026Trial
- Dynamic regulation of CD300b and CD300f on myeloid cells in oral immunotherapy.The journal of allergy and clinical immunology. Global · 2026Article
- Validation and reliability of the Italian versions of the Food Allergy Quality of Life -Parental Burden (FAQL-PB) and -Parent Form 10 (FAQLQ-PF10) Questionnaires.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Sesame Immunotherapy: A Systematic Review and Narrative Synthesis.Clinical and translational allergy · 2026Review
- Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target.Allergy · 2026Article
- Chia Seed Allergy: Emerging Clinical Evidence, Molecular Allergens, and the Unresolved Question of Cross-Reactivity.Nutrients · 2026Review
- Indications for Biological Treatment Combined with Allergen-Specific Immunotherapy: Who Is It Really Intended for?Journal of clinical medicine · 2026Review
- Evidence strength of exposure-outcome associations in pediatric allergic diseases: an umbrella review of meta-analyses.Pediatric research · 2026Review
- Clinical and immunological predictors of baked egg tolerance in children with IgE-mediated hen's egg allergy: a cross-sectional diagnostic accuracy study.European journal of pediatrics · 2026Article
- Update on biologic and small molecules treatments in pediatric allergic diseases.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Review
- Needle-to-bone safety margin of adrenaline auto-injectors in Japanese children: Impact of injection site variation.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Is age a critical factor for the diagnosis of peanut allergy in children?The World Allergy Organization journal · 2026Article
- Taste aversion and adverse events contribute equally to OIT discontinuation in children: A real-world multi-allergen analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Observational
- Individualized Nutritional and Microbiome-Oriented Management of Food Allergy-Associated Atopic Dermatitis in Children: A Prospective Real-World Observational Cohort Study.Foods (Basel, Switzerland) · 2026Article
- Observational
- Peripheral skin temperature during hospitalization and allergic disorders in non-NICU neonates >35 weeks.iScience · 2026Article
- Predictive Biomarker for Persistent Food Allergy in Children.Allergy, asthma & immunology research · 2026Article
- Prevalence of adverse reactions and food allergies in Colombia: Cross-sectional national study.The journal of allergy and clinical immunology. Global · 2026Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors.
Alexandra F SantosDepartment of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0002-7805-1436
Carmen RiggioniDivision of Immunology and Allergy, The Hospital for Sick Children and the SickKids Food Allergy and Anaphylaxis Program, Toronto, Ontario, Canada.ORCID 0000-0002-8745-0228
Ioana AgacheFaculty of Medicine, Transylvania University, Brasov, Romania.ORCID 0000-0001-7994-364X
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.ORCID 0000-0001-8020-019X
Mubeccel AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.ORCID 0000-0003-0554-9943
Alberto Alvarez-PereaHospital General Universitario Gregorio Marañón, Madrid, Spain.
Montserrat Alvaro-LozanoPediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain.
Barbara Ballmer-WeberClinic for Dermatology and Allergology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Simona BarniAllergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Kirsten BeyerDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
Carsten Bindslev-JensenDepartment of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Helen A BroughDepartment of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0001-7203-0813
Betul BuyuktiryakiDepartment of Pediatrics, Division of Pediatric Allergy, Koc University School of Medicine, Istanbul, Türkiye.
Derek ChuMcMaster University, Hamilton, Canada.
Stefano Del GiaccoDepartment of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.ORCID 0000-0002-4517-1749
Audrey Dunn-GalvinPaediatrics and Child Health, INFANT Centre, HRB-CRF, University College Cork, Cork, Ireland.ORCID 0000-0002-1540-3959
Bernadette EberleinDepartment of Dermatology and Allergy, Technical University of Munich, School of Medicine, Munich, Germany.ORCID 0000-0003-4509-6491
Motohiro EbisawaClinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.ORCID 0000-0003-4117-558X
Philippe EigenmannDepartment of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
Thomas EiweggerKarl Landsteiner University of Health Sciences, Krems an der Donau, Austria.
Mary FeeneyDepartment of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Montserrat Fernandez-RivasAllergy Department, Hospital Clinico San Carlos, Madrid, Spain.ORCID 0000-0003-1748-2328
Alessandro FiocchiAllergy Department, Pediatric Hospital Bambino Gesù IRCCS, Rome, Italy.
Helen R FisherDepartment of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0002-5958-4587
David M FleischerUniversity of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.
Mattia GiovanniniAllergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID 0000-0001-9568-6882
Claudia GrayRed Cross Children's Hospital and Kidsallergy Centre, Cape Town, South Africa.
Karin Hoffmann-SommergruberDept. of pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-8830-058X
Susanne HalkenHans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.ORCID 0000-0003-0161-8278
Jonathan O'B HourihaneRoyal College of Surgeons in Ireland and Childrens Health Ireland, Dublin, Ireland.
Christina J JonesSchool of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.ORCID 0000-0003-3672-6631
Marek JutelDepartment of Clinical Immunology, Faculty of Medicine, Wrocław Medical University; and ALL-MED Medical Research Institute, Wroclaw, Poland.
Edward F KnolDepartment Center of Translational Immunology and Department Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
George N KonstantinouDepartment of Allergy and Clinical Immunology, 424 General Military Training Hospital, Thessaloniki, Greece.ORCID 0000-0003-1371-6764
Gideon LackDepartment of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0001-7350-4021
Susanne LauDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-5189-4265
Andreina Marques MejiasDepartment of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0002-0237-5696
Mary Jane MarchisottoEAACI Patient Organisation Committee, Zurich, Switzerland.
Rosan MeyerDept. Nutrition and Dietetics, Winchester University, Winchester, UK.
Charlotte G MortzDepartment of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.ORCID 0000-0001-8710-0829
Beatriz MoyaDepartment of Allergy, Hospital Universitario 12 de Octubre, Madrid, Spain.ORCID 0000-0001-7730-2785
Antonella MuraroFood Allergy Referral Centre, Padua University Hospital, Padua, Italy.
Caroline NilssonDepartment of Clinical Science and Education, Karolinska Institutet, Solna, Sweden.
Lucila Camargo Lopes de OliveiraDivision of Allergy and Clinical Immunology, Department of Paediatrics, Federal University of São Paulo, São Paulo, Brazil.
Liam O'MahonyDepartment of Medicine, School of Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0003-4705-3583
Nikolaos G PapadopoulosAllergy Dpt, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
Kirsten P PerrettPopulation Allergy, Murdoch Children's Research Institute, Parkville, Australia.
Rachel PetersMurdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0002-2411-6628
Marcia PodestaEuropean Federation of Allergy and Airways Diseases Patients' Associations and the EAACI Patient Organisation Committee, Zurich, Switzerland.
Lars K PoulsenAllergy Clinic, Copenhagen University Hospital at Herlev-Gentofte, Copenhagen, Denmark.ORCID 0000-0002-1730-847X
Graham RobertsPaediatric Allergy and Respiratory Medicine, University of Southampton, NIHR Southampton Biomedical Research Centre and David Hide Asthma and Allergy Centre, St Mary Hospital, Isle of Wight, UK.ORCID 0000-0003-2252-1248
Hugh SampsonDepartment of Pediatrics, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jürgen SchwarzeChild Life and Health, Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
Peter SmithClinical Medicine, Griffith University, Southport, Queensland, Australia.
Elizabeth ThamYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Eva UntersmayrInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1963-499X
Ronald Van ReeDepartment of Experimental Immunology and of Otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Carina VenterSection of Allergy and Clinical Immunology, Children's Hospital Colorado, University of Colorado, Boulder, Colorado, USA.
Brian VickeryEmory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.ORCID 0000-0002-7243-5543
Berber Vlieg-BoerstraDepartment of Paediatrics, OLVG Hospital, Amsterdam, the Netherlands.ORCID 0000-0001-7962-5406
Thomas WerfelDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Margitta WormDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-3449-1245
George Du ToitDepartment of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0002-0321-2928
Isabel SkypalaPart of Guys and St Thomas NHS Foundation Trust, Royal Brompton and Harefield Hospitals, London, UK.ORCID 0000-0003-3629-4293
Funding
European Academy of Allergy and Clinical Immunology
Abstract
This European Academy of Allergy and Clinical Immunology (EAACI) guideline provides recommendations for the management of IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Following the confirmation of IgE-mediated food allergy diagnosis, allergen avoidance and dietary advice (with support of a specialised dietitian, if possible) together with the provision of a written treatment plan, education on the recognition of allergic symptoms and prescription of medication including adrenaline using an auto-injector are essential. Patients with significant anxiety and requirement for coping strategies may benefit from support from a clinical psychologist. As immunomodulatory interventions, omalizumab is suggested for treatment of IgE-mediated food allergy in children from the age of 1 and adults; and oral allergen-specific immunotherapy is recommended for children and adolescents with peanut allergy and suggested for milk and egg allergies (generally after 4 years of age for milk and egg). Sublingual and epicutaneous immunotherapy are suggested for peanut allergy but are not yet available at the point of care. Future research into disease modifying treatments for IgE-mediated food allergy are highly needed, with standardised and patient-focused protocols and outcomes.
Indexed as
Food HypersensitivityImmunoglobulin EAllergensChildDesensitization, ImmunologicDisease ManagementHumansAllergensImmunoglobulin Eallergen immunotherapyanaphylaxisbiologicalsdietfood allergyIgE‐mediated food allergymanagementtreatment
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Read underepoch 390
Registered trials
NCT07764159ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.