Evidence map›Paper›PMID 39473330›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2024

Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement.

Nazareth Milagros Carigga Gutierrez, Tristan Le Clainche, Anne-Laure Bulin, Sofia Leo, Malika Kadri, Ahmed Gamal Ali Abdelhamid, Núria Pujol-Solé, Girgis Obaid, Marc-André Hograindleur, Vincent Gardette and 11 more

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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  5. Multifunctional CuFrontiers in chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nazareth Milagros Carigga GutierrezUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Tristan Le ClaincheUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Anne-Laure BulinUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Sofia LeoUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Malika KadriUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Ahmed Gamal Ali AbdelhamidUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Núria Pujol-SoléUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Girgis ObaidDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA.
Marc-André HograindleurEuropean Synchrotron Radiation Facility, CM01 Beamline, 71 Avenue des Martyrs, Grenoble, 38000, France.
Vincent GardetteUniversité Lyon 1, Institut Lumière Matière, CNRS UMR 5306, Université de Lyon, Villeurbanne, France.
Benoit BusserUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Vincent Motto-RosUniversité Lyon 1, Institut Lumière Matière, CNRS UMR 5306, Université de Lyon, Villeurbanne, France.
Véronique JosserandUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Maxime HenryUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Lucie SanceyUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Amandine HurbinUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Hélène ElleaumeUniversité de Grenoble-Alpes, Synchrotron Radiation for Biomedicine, Inserm UA07, 2280 Rue de la Piscine, Saint Martin d'Hères, 38400, France.
Eaazhisai KandiahDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA.
Xavier Le GuévelUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Jean-Luc CollUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.ORCID 0000-0002-2453-3552
Mans BroekgaardenUniversité Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.

Funding

Agence National de la Recherche ANR-20CE09-0039-01European Synchrotron Radiation Facility for the provision of beam time on MD-1216 MD-1294European Synchrotron Radiation Facility for the provision of beam time on MD-1320HORIZON EUROPE European Research Council 101078392HORIZON EUROPE European Research Council 101116304InsermInstitute for Advanced Biosciences ANR-10-INBS-04Institute for Advanced Biosciences CNRS 5309Institute for Advanced Biosciences U1209Phospholipid Research Center MAB- 2020- 080/1- 1
6 · The paper itself

Abstract

Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic nanomaterials to cancer tissues. In this study, the interaction between X-rays and long-circulating nanoliposome formulations loaded with gold nanoclusters is explored in the context of oxaliplatin chemotherapy for desmoplastic pancreatic cancer. Hydrophobic gold nanoclusters stabilized with dodecanethiol (AuDDT) are efficiently incorporated in nanoliposomal bilayers. AuDDT-nanoliposomes significantly augmented radiation-induced

Indexed as

GoldHydrophobic and Hydrophilic InteractionsLiposomesMetal NanoparticlesPancreatic NeoplasmsAnimalsCell Line, TumorHumansMiceOxaliplatinSulfhydryl CompoundsGoldLiposomesOxaliplatinSulfhydryl Compounds3D culture modelschemoradiotherapylipid nanotechnologymonochromatic synchrotron radiationoxaliplatinpancreatic cancerradiation therapyradiotherapy‐controlled drug deliverytumor permeability

Identifiers

PMID39473330
PMCPMC11636064

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.