ArticleMagnetic resonance in medicine2025
Revealing membrane integrity and cell size from diffusion kurtosis time dependence.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Investigating the Sensitivity of the Diffusion MRI Signal to Magnetization Transfer and Permeability via Monte-Carlo Simulations.Magnetic resonance in medicine · 2026Article
- Complementary Sensitivity of Fixed-Time and Fixed-Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating-Gradient Diffusion MRI With Ultra-Strong Gradients.Magnetic resonance in medicine · 2026Article
- What If Each Voxel Were Measured With a Different Diffusion Protocol?Magnetic resonance in medicine · 2026Article
- Article
- Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.Magnetic resonance in medicine · 2025Article
- Evaluating a Cellular Microstructure Model Within Apoptotic Cell Death via Diffusion Magnetic Resonance and Long Diffusion Times.NMR in biomedicine · 2025Article
- Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from transient kurtosis.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeThe nonmonotonic dependence of diffusion kurtosis on diffusion time has been observed in biological tissues, yet its relation to membrane integrity and cellular geometry remains to be clarified. Here we establish and explain the characteristic asymmetric shape of the kurtosis peak. We also derive the relation between the peak time
methodsThe peak shape and its position
resultsWe establish that
conclusionNumerical simulations and theory provide an interpretation of a specific feature of kurtosis time-dependence, offering a potential biomarker for in vivo evaluation of pathology by disentangling the functional (permeability) and structural (cell size) integrity in tissues. This is relevant as the time-dependent diffusion cumulants are sensitive to pathological changes in membrane integrity and cellular structure in diseases, such as ischemic stroke, tumors, and Alzheimer's disease.
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Registered trials
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