Evidence map›Paper›PMID 39473106›Full record

ArticleMicroRNA (Shariqah, United Arab Emirates)2025

Identification of Key miRNAs in Endometriosis.

Francesca Blandino, Saviana Antonella Barbati, Luca Forlani, Giulia Coppola, Noemi Meschino, Ilde Cecchinelli, Antonietta Cosco Mazzuca, Valentina Veltri, Riccardo Giannico, Graziella Calugi

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Article in MicroRNA (Shariqah, United Arab Emirates), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Francesca BlandinoDepartment of Research and Development, Eurofins Genoma Group, Rome, Italy.
Saviana Antonella BarbatiDepartmental Faculty of Medicine and Surgery, UniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy.ORCID 0000-0002-7574-0201
Luca ForlaniDepartment of Bioinformatics, Eurofins Genoma Group, Rome, Italy.
Giulia CoppolaDepartment of Medical Oncology and Pathology Unit, San Filippo Neri Hospital, ASL RM1, Rome, Italy.
Noemi MeschinoDepartment of Research and Development, Eurofins Genoma Group, Rome, Italy.
Ilde CecchinelliDepartment of Anatomical Pathology Research and Development, Samar srl Histology Lab, Rome, Italy.
Antonietta Cosco MazzucaDepartment of Anatomical Pathology Research and Development, Samar srl Histology Lab, Rome, Italy.
Valentina VeltriDepartment of Anatomical Pathology Research and Development, Samar srl Histology Lab, Rome, Italy.
Riccardo GiannicoDepartment of Bioinformatics, Eurofins Genoma Group, Rome, Italy.
Graziella CalugiDepartment of Research and Development, Eurofins Genoma Group, Rome, Italy.ORCID 0009-0007-6001-1552

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEndometriosis, a prevalent gynecological disorder characterized by the presence of endometrial-like tissue outside the uterus, poses significant challenges in diagnosis and management due to its unclear pathogenesis and lack of specific biomarkers.

objectiveThis study investigates the potential use of microRNAs (miRNAs) as key markers in endometriosis by studying two cohorts of patients (14 patients diagnosed with endometriosis and 15 patients with gynecological benign lesions, different from endometriosis).

methodsMicroRNA sequencing analysis was tested within data management by a custom pipeline designed by Eurofins Genoma Group.

resultsWe identified a specific miRNA expression profile associated with endometriosis to feature specific disease molecular clusters to further elucidate the underlying mechanisms driving endometriosis pathogenesis. Data from the present study suggest a specific miRNA scar for endometriosis compared to other gynecological diseases to develop screening tools in early diagnosis and to ameliorate the management of the disease itself.

conclusionThis study lays the foundation for the identification of key miRNAs involved in the disease pathogenesis to unveil the molecular signatures in the complex scenario of endometriosis. Further validation and exploration of these findings are needed to develop tools to improve molecular diagnosis and to create a machine-learning prediction algorithm in the future.

Indexed as

EndometriosisMicroRNAsAdultBiomarkersFemaleGene Expression ProfilingHumansBiomarkersMicroRNAsEndometriosisendometrium.gynecologymicroRNAmiRNAwomen

Identifiers

PMID39473106

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.