Evidence map›Paper›PMID 39472600›Full record

ArticleScientific reports2024

Lipoprotein (a) is not associated with thrombus burden derived from CT pulmonary angiography in patients with acute pulmonary embolism.

Paul Gressenberger, Florian Posch, Gabriel Adelsmayr, Eszter Nagy, Ann-Katrin Kaufmann-Bühler, Jakob Steiner, Michael Janisch, Clemens Reiter, Martin Eibisberger, Elmar Janek and 9 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Paul GressenbergerDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Florian PoschDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Gabriel AdelsmayrDivision of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, Graz, 8036, Austria. gabriel.adelsmayr@medunigraz.at.
Eszter NagyDivision of Paediatric Radiology, Department of Radiology, Medical University of Graz, Graz, Austria.
Ann-Katrin Kaufmann-BühlerDivision of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, Graz, 8036, Austria.
Jakob SteinerDivision of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, Graz, 8036, Austria.
Michael JanischDivision of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria.
Clemens ReiterDivision of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria.
Martin EibisbergerDivision of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria.
Elmar JanekDivision of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, Graz, 8036, Austria.
Nina SofticDivision of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, Graz, 8036, Austria.
Michael FuchsjägerDivision of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, Graz, 8036, Austria.
Katharina GütlDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Philipp JudDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Günther SilbernagelDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Reinhard B RaggamDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Marianne BrodmannDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Thomas GaryDivision of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Johannes SchmidDivision of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, Graz, 8036, Austria. johannes.schmid@medunigraz.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein (a) [Lp(a)] is suspected to have antifibrinolytic effects, however, its relevance for the severity of venous thromboembolic events remains unclear. We studied the association of Lp(a) levels with thrombus load in pulmonary embolism (PE). 90 patients (40% female, median age 70 [56-79] years) at our tertiary care hospital with a diagnosis of acute PE, available Lp(a) levels and CT pulmonary angiography (CT-PA) performed between April 2017 and December 2019 were included. All CT-PA scans were reanalyzed and thrombus load was determined via Qanadli CT obstruction index (CTOI) and most proximal thrombus location. Median Lp(a) levels were 11.4 [9.3-29.1] mg/dL, median D-dimer levels were 4.6 [2.1-9.8] mg/L, median CTOI was 23 [8-50], central PE was present in 27 (30%) patients. Lp(a) did not correlate with CTOI (r = 0.02, p = 0.922) and was not associated with thrombus location (p = 0.369). CTOI significantly correlated with D-dimer (r = 0.43, p < 0.001) and right to left ventricular diameter ratio (r=-0.49, p = < 0.001). Our findings showed that Lp(a) is not associated with thrombus burden in PE, which suggests that a relevant effect of Lp(a) on the extent of venous thromboembolism is unlikely.

Indexed as

Computed Tomography AngiographyLipoprotein(a)Pulmonary EmbolismAcute DiseaseAgedFemaleFibrin Fibrinogen Degradation ProductsHumansMaleMiddle AgedRetrospective StudiesThrombosisFibrin Fibrinogen Degradation Productsfibrin fragment DLipoprotein(a)

Identifiers

PMID39472600
PMCPMC11522666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.