Evidence map›Paper›PMID 39472532›Full record

ArticleScientific reports2024

Metabolite changes by combined treatment, ethyl formate and low temperature, in Drosophila suzukii.

Junbeom Lee, Hyun-Kyung Kim, Jong-Chan Jeon, Seung-Ju Seok, Gil-Hah Kim, Hyun-Na Koo, Dae-Weon Lee

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Comparative Metabolomics Reveals Phosphine-Induced Metabolic Disruptions inInternational journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junbeom LeeMetabolomics Research Center for Functional Materials, Kyungsung University, Busan, 48434, Republic of Korea.
Hyun-Kyung KimDepartment of Plant Medicine, College of Agriculture, Life and Environment Science, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Jong-Chan JeonDepartment of Plant Medicine, College of Agriculture, Life and Environment Science, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Seung-Ju SeokDepartment of Plant Medicine, College of Agriculture, Life and Environment Science, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Gil-Hah KimDepartment of Plant Medicine, College of Agriculture, Life and Environment Science, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Hyun-Na KooDepartment of Plant Medicine, College of Agriculture, Life and Environment Science, Chungbuk National University, Cheongju, 28644, Republic of Korea. 913029@cbnu.ac.kr.
Dae-Weon LeeMetabolomics Research Center for Functional Materials, Kyungsung University, Busan, 48434, Republic of Korea. daeweonlee@ks.ac.kr.

Funding

Animal and Plant Quarantine Agency Z-1543086-2021-23-05Korea Basic Science Institute 2019R1A6C1010044Ministry of Education RS-2023-00245952
6 · The paper itself

Abstract

Although ethyl formate (EF) fumigant and low temperature applications are widely used for pest management, studies related to their mechanisms of action and subsequent metabolic changes in Drosophila suzukii models are still unclear. In this study, a comparative metabolome analysis was performed to investigate the major metabolites modified by EF and low temperature and how they are related to and affect insect physiology. Most of the identified metabolites function in metabolic pathways related to the biosynthesis of amino acids, nucleotides and cofactors. In addition, a combined treatment with EF and low temperature significantly altered the tricarboxylic acid cycle (TCA) and the levels of the purine and pyrimidine classes of metabolites. Interestingly, the levels of cytochrome P450 and glutathione metabolites involved in detoxification dramatically changed under stress conditions compared to those in the control group.

Indexed as

Cold TemperatureDrosophilaFormic Acid EstersMetabolomeAnimalsCitric Acid CycleCytochrome P-450 Enzyme SystemGlutathioneMetabolomicsCytochrome P-450 Enzyme Systemethyl formateFormic Acid EstersGlutathioneDrosophila suzukiiEthyl formateLow temperatureMetabolomicsSphingolipids

Identifiers

PMID39472532
PMCPMC11522300

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.