Evidence map›Paper›PMID 39472330›Full record

ArticleMikrochimica acta2024

Cost-effective chemiresistive biosensor with MWCNT-ZnO nanofibers for early detection of tuberculosis (TB) lipoarabinomannan (LAM) antigen.

Dinesh R Rotake, Jitendra B Zalke, Harsh V Gechode, Sandhini M Peshkar, Shiv Govind Singh

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dinesh R RotakeDepartment of Electrical Engineering, Indian Institute of Technology, Hyderabad, India. dinesh.rotake@gmail.com.
Jitendra B ZalkeDepartment of Electronics Engineering, Ramdeobaba University, Nagpur, India. zalkej@rknec.edu.
Harsh V GechodeDepartment of Electronics Engineering, Ramdeobaba University, Nagpur, India.
Sandhini M PeshkarDepartment of Electronics Engineering, Ramdeobaba University, Nagpur, India.
Shiv Govind SinghDepartment of Electrical Engineering, Indian Institute of Technology, Hyderabad, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of an affordable chemiresistive biosensor enhanced with a multi-walled carbon nanotube-zinc oxide (MWCNT-ZnO) nanofiber composite is presented. The sensor leverages the precise interaction between lipoarabinomannan (LAM) tuberculosis (TB) antigens and antibodies to achieve high sensitivity and specificity. The MWCNT-ZnO nanofibers have a larger surface area and better electrical conductivity, which makes it easier for TB antibodies to stick to them. The binding of LAM TB antigens to the fixed Monoclonal Antibody-MBS320597 induces significant resistance changes in the chemiresistive sensor, enabling accurate TB detection. Performance evaluation reveals a linear detection range from 1.0 to 100.0 pg/mL in the lower concentration range and up to 6.0 ng/mL in the higher concentration range, with a sensitivity of 79.750 mA pg mL

Indexed as

Biosensing TechniquesLipopolysaccharidesNanofibersNanotubes, CarbonTuberculosisZinc OxideAntibodies, ImmobilizedAntigens, BacterialHumansLimit of DetectionMycobacterium tuberculosisAntibodies, ImmobilizedAntigens, BacteriallipoarabinomannanLipopolysaccharidesNanotubes, CarbonZinc OxideAntibodiesInterdigitated electrodes (IDEs)Lipoarabinomannan (LAM)MWCNT-ZnO nanofibersMycobacterium tuberculosis (MTB)TB antigen

Identifiers

PMID39472330

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.