Evidence map›Paper›PMID 39471873›Full record

ArticleJournal of the Royal Society, Interface2024

Reconciling founder variant multiplicity of HIV-1 infection with the rate of CD4

James Baxter, Ch Julián Villabona-Arenas, Robin N Thompson, Stéphane Hué, Roland R Regoes, Roger D Kouyos, Huldrych F Günthard, Jan Albert, Andrew Leigh Brown, Katherine E Atkins

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James BaxterUsher Institute, Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-6598-1784
Ch Julián Villabona-ArenasFaculty of Epidemiology and Population Health, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-9928-3968
Robin N ThompsonMathematical Institute, University of Oxford, Oxford OX2 6GG, UK.ORCID 0000-0001-8545-5212
Stéphane HuéFaculty of Epidemiology and Population Health, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-8580-6905
Roland R RegoesDepartment of Environmental Systems Science, Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland.ORCID 0000-0001-8319-5293
Roger D KouyosDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-9220-8348
Huldrych F GünthardDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-1142-6723
Jan AlbertDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0001-9020-0521
Andrew Leigh BrownInstitute of Evolutionary Ecology, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5700-3128
Katherine E AtkinsUsher Institute, Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5250-0558

Funding

European Research CouncilMedical Research Council
6 · The paper itself

Abstract

HIV-1 transmission precipitates a stringent genetic bottleneck, with 75% of new infections initiated by a single genetic variant. Where multiple variants initiate infection, recipient set point viral load (SpVL) and the rate of CD4

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV InfectionsCD4 Lymphocyte CountHumansViral LoadbioinformaticsHIV/AIDSinfectious disease dynamics

Identifiers

PMID39471873
PMCPMC11606301

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.