Evidence map›Paper›PMID 39471840›Full record

ArticleOpen biology2024

Internal regulation between constitutively expressed T cell co-inhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants.

Adeolu O Adegoke, Govindarajan Thangavelu, Ting-Fang Chou, Marcos I Petersen, Kiyokazu Kakugawa, Julia F May, Kevin Joannou, Qingyang Wang, Kristofor K Ellestad, Louis Boon and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Adeolu O AdegokeDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-0886-9678
Govindarajan ThangaveluDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Ting-Fang ChouLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Marcos I PetersenDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Kiyokazu KakugawaLaboratory for Immune Crosstalk, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan.
Julia F MayDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Kevin JoannouDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Qingyang WangLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Kristofor K EllestadAlberta Diabetes and Transplant Institutes, University of Alberta, Edmonton, AB, Canada.
Louis BoonJJP Biologics, Warsaw, Poland.
Peter A BretscherDepartment of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Hilde CheroutreLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Mitchell KronenbergLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-6318-6445
Troy A BaldwinDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-0122-3746
Colin C AndersonDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-1733-4237

Funding

HVEM: A TNF family receptor that influences mucosal immunity and the microbiomeU01AI125955 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2016 to 2020
$2.7M
VWF Activity: Molecular Biology, Ethnic Diversity and Disease AssociationsR01HL125957 · NHLBI · BLOODWORKS · PI DONG, JING-FEI, YU, FULI · 2015 to 2018
$2.5M
CIHRNatural Sciences and Engineering Research Council of CanadaNHLBI NIH HHS R01 HL125957NIAID NIH HHS U01 AI125955NIH HHS
6 · The paper itself

Abstract

Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA are expressed constitutively. The relationship between constitutively expressed co-inhibitors and when they are needed is unknown. Deletion of

Indexed as

CD5 AntigensReceptors, ImmunologicThymus GlandAnimalsGene Expression RegulationImmune ToleranceMiceMice, KnockoutProgrammed Cell Death 1 ReceptorSignal TransductionBTLA protein, mouseCD5 AntigensCd5 protein, mousePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, ImmunologicautoimmunityBTLACD5recent thymic emigrantsT cellstolerance

Identifiers

PMID39471840
PMCPMC11521602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.