ArticleCell metabolism2025
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones.
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Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed.
- Research progress on ATP-citrate lyase and its inhibitors: a metabolic-epigenetic perspective.Journal of enzyme inhibition and medicinal chemistry · 2026Review
- Dietary Fermented Strawberry Pomace Improves Yolk Lipid Quality and Modulates Reproductive Endocrine Activity, Intestinal Barrier Status, and Cecal Microbiota in Laying Hens.Foods (Basel, Switzerland) · 2026Article
- Acetyl-CoA-dependent processes are preferentially supported by local metabolite synthesis.Science advances · 2026Article
- Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis.Trends in endocrinology and metabolism: TEM · 2026Review
- Decoding the Gut-Fat-Heart Axis: From Molecular Communication Networks to Clinical Translation Strategies.International journal of molecular sciences · 2026Review
- Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation.Nature neuroscience · 2026Article
- Current Drug Development Pipeline for MASLD and MASH: Focusing on Cardiovascular Comorbidities.Biomedicines · 2026Review
- Incretin and Glucagon Signalling in MASLD and MASH: Integrating Metabolic Pathways With Disease Progression.Diabetes, obesity & metabolism · 2026Review
- A Global Perspective on Metabolic Dysfunction-Associated Steatotic Liver Disease: From Molecular Mechanisms to Therapeutic Strategy Innovation.Nutrients · 2026Review
- Multi-omics dynamic profiling reveals predictive biomarkers for first-line immunochemotherapy in extensive-stage small-cell lung cancer.Journal of translational medicine · 2026Article
- Integrated Transcriptomic and Proteomic Analysis Associated with Knockdown and Overexpression Studies Revealed ECHDC1 as a Regulator of Intramuscular Fat Deposition in Cattle.Animals : an open access journal from MDPI · 2025Article
- An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells.Nature metabolism · 2025Article
- Molecular targets of bempedoic acid and related decoy fatty acids.Trends in endocrinology and metabolism: TEM · 2025Review
- MASH: the nexus of metabolism, inflammation, and fibrosis.The Journal of clinical investigation · 2025Review
- Role of amino acids in the regulation of hepatic gluconeogenesis and lipogenesis in metabolic dysfunctionassociated steatotic liver disease.Clinical and molecular hepatology · 2025Review
- Sex-specific microbiota associations with backfat thickness, eye muscle area, and rumen fermentation in Qinchuan cattle.BMC microbiology · 2025Article
- Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation.Science advances · 2025Article
- The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export.Science advances · 2025Article
- Advancing de novo lipogenesis: Genetic and metabolic insights.Cell metabolism · 2025Article
- Network Pharmacology and Serum Nontargeted Metabolomics Reveal the Protective Effects of Propionate Against Liver Damage Induced by a High-Fat and AGE-Rich Diet in Diabetic Mice.Journal of diabetes research · 2025Article
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Authors and funding
12 authors.
Adam J RauckhorstDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Fraternal Order of Eagles Diabetes Research Center (FOEDRC), University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; FOEDRC Metabolomics Core Research Facility, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Ryan D SheldonDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Daniel J PapeDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Adnan AhmedDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Kelly C Falls-HubertDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Ronald A MerrillDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Reid F BrownDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; FOEDRC Metabolomics Core Research Facility, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Kshitij DeshmukhDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.
Thomas A VallimDepartment of Biological Chemistry, University of California, Los Angeles (UCLA), David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Stanislaw DejaCenter for Human Nutrition, University of Texas Southwestern, Dallas, TX 75390, USA.
Shawn C BurgessCenter for Human Nutrition, University of Texas Southwestern, Dallas, TX 75390, USA.
Eric B TaylorDepartment of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Fraternal Order of Eagles Diabetes Research Center (FOEDRC), University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; FOEDRC Metabolomics Core Research Facility, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA. Electronic address: eric-taylor@uiowa.edu.
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4MFactors controlling metabolic flux in the liver - Supplement RevisionR01DK078184 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Shawn C Burgess · 2008 to 2026
$6.8MPROGRAM IN HEMOSTASIS AND THROMBOSIS FOR ACADEMICT32HL007344 · NHLBI · UNIVERSITY OF IOWA · PI Anil Kumar Chauhan, Steven R Lentz · 1985 to 2026
$6.5MMedical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4MDiabetes Research Training Program Diversity SupplementT32DK112751 · NIDDK · UNIVERSITY OF IOWA · PI Andrew W Norris · 2017 to 2026
$4.8MRegulation of Hepatic Macronutrient Metabolism by Mitochondrial Citrate TransportR01DK104998 · NIDDK · UNIVERSITY OF IOWA · PI TAYLOR, ERIC B · 2015 to 2022
$3.2MRegulation of lipogenesis by TCA cycle metabolismR01DK128168 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURGESS, SHAWN C · 2021 to 2025
$2.1MRegulation of Hepatic Fuel Fluxes by the Mitochondrial Dicarboxylate CarrierR01DK138664 · NIDDK · UNIVERSITY OF IOWA · PI Eric B Taylor · 2024 to 2026
$1.5MSympathetic Control of Liver Metabolism in Exercise and ObesityK01DK133630 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Stanislaw Marek Deja · 2022 to 2026
$518kRegulation of Hepatic Lipogenesis by a Mitochondrial Pyruvate Carrier-Citrate Carrier AxisF32DK116522 · NIDDK · UNIVERSITY OF IOWA · PI SHELDON, RYAN DOUGLAS · 2017 to 2018
$81kAmerican Heart Association-American Stroke Association 851976NCI NIH HHS P30 CA086862NHLBI NIH HHS T32 HL007344NIDDK NIH HHS F32 DK116522NIDDK NIH HHS K01 DK133630NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK078184NIDDK NIH HHS R01 DK104998NIDDK NIH HHS R01 DK128168NIDDK NIH HHS R01 DK138664NIDDK NIH HHS T32 DK112751NIGMS NIH HHS T32 GM007337NIGMS NIH HHS T32 GM139776
Abstract
Hepatic de novo lipogenesis (DNL) is a fundamental physiologic process that is often pathogenically elevated in metabolic disease. Treatment is limited by incomplete understanding of the metabolic pathways supplying cytosolic acetyl-CoA, the obligate precursor to DNL, including their interactions and proportional contributions. Here, we combined extensive
Indexed as
LipogenesisLiverMice, KnockoutPyruvic AcidAcetate-CoA LigaseAcetatesAcetoacetatesAcetyl Coenzyme AAnimalsATP Citrate (pro-S)-LyaseKetonesMaleMiceMitochondriaMitochondrial Membrane Transport ProteinsMonocarboxylic Acid TransportersAcetate-CoA LigaseAcetatesAcetoacetatesacetoacetic acidAcetyl Coenzyme AACSS2 protein, mouseATP Citrate (pro-S)-LyaseKetonesMitochondrial Membrane Transport ProteinsMonocarboxylic Acid TransportersPyruvic AcidAACSacetoacetyl-CoA synthetaseacetyl-CoA synthetase 2ACLYACSS2ATP-citrate lyaseCiCde novo lipogenesisDNLlivermetabolomicsmitochondrial citrate carriermitochondrial pyruvate carrierMPCstable isotope tracers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.