Evidence map›Paper›PMID 39471790›Full record

ArticleCaries research2025

Deep Learning-Based Algorithm for Staging Secondary Caries in Bitewings.

Niels van Nistelrooij, Eduardo Trota Chaves, Maximiliano Sergio Cenci, Lingyun Cao, Bas A C Loomans, Tong Xi, Khalid El Ghoul, Vitor Henrique Digmayer Romero, Giana Silveira Lima, Tabea Flügge and 4 more

Abstract read
In one paragraph

Article in Caries research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Niels van NistelrooijDepartment of Oral and Maxillofacial Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Eduardo Trota ChavesDepartment of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands.
Maximiliano Sergio CenciDepartment of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands.
Lingyun CaoDepartment of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands.
Bas A C LoomansDepartment of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands.
Tong XiDepartment of Oral and Maxillofacial Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Khalid El GhoulDepartment of Oral and Maxillofacial Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Vitor Henrique Digmayer RomeroDepartment of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands.
Giana Silveira LimaGraduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Brazil.
Tabea FlüggeDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Bram van GinnekenDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Marie-Charlotte HuysmansDepartment of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands.
Shankeeth VinayahalingamDepartment of Oral and Maxillofacial Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Fausto Medeiros MendesDepartment of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite the notable progress in developing artificial intelligence-based tools for caries detection in bitewings, limited research has addressed the detection and staging of secondary caries. Therefore, we aimed to develop a convolutional neural network (CNN)-based algorithm for these purposes using a novel approach for determining lesion severity.

methodsWe used a dataset from a Dutch dental practice-based research network containing 2,612 restored teeth in 413 bitewings from 383 patients aged 15-88 years and trained the Mask R-CNN architecture with a Swin Transformer backbone. Two-stage training fine-tuned caries detection accuracy and severity assessment. Annotations of caries around restorations were made by two evaluators and checked by two other experts. Aggregated accuracy metrics (mean ± standard deviation - SD) in detecting teeth with secondary caries were calculated considering two thresholds: detecting all lesions and dentine lesions. The correlation between the lesion severity scores obtained with the algorithm and the annotators' consensus was determined using the Pearson correlation coefficient and Bland-Altman plots.

resultsOur refined algorithm showed high specificity in detecting all lesions (0.966 ± 0.025) and dentine lesions (0.964 ± 0.019). Sensitivity values were lower: 0.737 ± 0.079 for all lesions and 0.808 ± 0.083 for dentine lesions. The areas under ROC curves (SD) were 0.940 (0.025) for all lesions and 0.946 (0.023) for dentine lesions. The correlation coefficient for severity scores was 0.802.

conclusionWe developed an improved algorithm to support clinicians in detecting and staging secondary caries in bitewing, incorporating an innovative approach for annotation, considering the lesion severity as a continuous outcome.

Indexed as

AlgorithmsDeep LearningDental CariesAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeural Networks, ComputerSensitivity and SpecificitySeverity of Illness IndexYoung AdultArtificial intelligenceCaries detectionConvolutional neural networkDiagnostic imagingRadiography

Identifiers

PMID39471790
PMCPMC12263131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.